Ten challenges for clinical translation in psychiatric genetics

EM Derks, JG Thorp, ZF Gerring - Nature Genetics, 2022 - nature.com
Genome-wide association studies have identified hundreds of robust genetic associations
underlying psychiatric disorders and provided important biological insights into disease …

Leveraging pleiotropy for the improved treatment of psychiatric disorders

DJ Woodward, JG Thorp, CM Middeldorp… - Molecular …, 2024 - nature.com
Over 90% of drug candidates fail in clinical trials, while it takes 10–15 years and one billion
US dollars to develop a single successful drug. Drug development is more challenging for …

The genetic landscape of substance use disorders

ZF Gerring, JG Thorp, JL Treur, KJH Verweij… - Molecular …, 2024 - nature.com
Substance use disorders represent a significant public health concern with considerable
socioeconomic implications worldwide. Twin and family-based studies have long …

Genetic and phenotypic similarity across major psychiatric disorders: a systematic review and quantitative assessment

VR Bourque, C Poulain, C Proulx, CA Moreau… - Translational …, 2024 - nature.com
There is widespread overlap across major psychiatric disorders, and this is the case at
different levels of observations, from genetic variants to brain structures and function and to …

Association between parental psychiatric disorders and risk of offspring autism spectrum disorder: a Swedish and Finnish population-based cohort study

W Yin, A Pulakka, A Reichenberg… - The Lancet Regional …, 2024 - thelancet.com
Background Roughly more than one in six adults worldwide suffer from psychiatric
conditions. Sporadic studies have associated parental psychiatric disorders with autism …

xWAS analysis in neuropsychiatric disorders by integrating multi-molecular phenotype quantitative trait loci and GWAS summary data

L Luo, T Pang, H Zheng, C Liufu, S Chang - Journal of Translational …, 2024 - Springer
Background Integrating quantitative trait loci (QTL) data related to molecular phenotypes
with genome-wide association study (GWAS) data is an important post-GWAS strategic …

No gene to predict the future?

A McNeill - European Journal of Human Genetics, 2022 - nature.com
All powerful technology has the potential to cause harm. Genomic testing is no exception.
How, you might reasonably ask, can such a seemingly innocuous procedure cause harm …

[引用][C] Correlation Scan: developing and applying a new method to uncover the genomic locations that affect the genetic correlations between traits

B Olasege - 2023 - espace.library.uq.edu.au
As the world faces the challenge of increasing sustainable food production for a growing
population amidst climate change and limited resources, animal breeders must double meat …