Dopamine receptors are abundant along the central nigrostriatal tract and are expressed as
5 subtypes in two receptor families. In PD, compensatory changes in dopamine receptors …

The limbic system describes a complex of brain structures central for memory, learning, as
well as goal directed and emotional behavior. In addition to pathological studies, recent …

Depression is a frequent non-motor symptom of Parkinson's disease (PD), and may even
precede the onset of motor symptoms of parkinsonism. Beyond its negative influence on …

Depression and neurocognitive disorder continue to be the major neuropsychiatric disorders
affecting persons with HIV (PWH). The prevalence of major depressive disorder is two to …

Adenosine and dopamine interact antagonistically in living mammals. These interactions are
mediated via adenosine A2A and dopamine D2 receptors (R). Stimulation of A2AR inhibits …

Parkinson's disease (PD) is a widespread progressive neurodegenerative disease. Clinical
diagnosis approaches are insufficient to provide an early and accurate diagnosis before a …

The dopaminergic system is one of the most important neurotransmitter systems in the
central nervous system (CNS). It acts mainly by activation of the D1-like receptor family at the …

Parkinson's disease (PD) is characterized by dysfunction in frontal cortical and striatal
networks that regulate action control. We investigated the pharmacological effect of …

As a result of neuro-vascular coupling, the functional effects of antipsychotics in human brain
have been investigated in both healthy and clinical populations using haemodynamic …

Radiotracers along with single photon emission computed tomography (SPECT) and
positron emission computed tomography (PET) instruments have led to significant advances …