The transcription factor SOX2 is essential for embryonic development and plays a crucial
role in maintaining the stemness of embryonic cells and various adult stem cell populations …

Dental enamel is the hardest and most mineralized tissue in extinct and extant vertebrate
species and provides maximum durability that allows teeth to function as weapons and/or …

Understanding cell types and mechanisms of dental growth is essential for reconstruction
and engineering of teeth. Therefore, we investigated cellular composition of growing and …

SOX2 is a well-characterized pluripotent factor that is essential for stem cell self-renewal,
reprogramming, and homeostasis. The cellular levels of SOX2 are precisely regulated by a …

Sox family transcription factors are well-established regulators of cell fate decisions during
development. Accumulating evidence documents that they play additional roles in adult …

The tooth provides an excellent system for deciphering the molecular mechanisms of
organogenesis, and has thus been of longstanding interest to developmental and stem cell …

Mesenchymal stem cells (MSCs) are typically defined by their in vitro characteristics, and as
a consequence the in vivo identity of MSCs and their niches are poorly understood. To …

The tooth root is an integral, functionally important part of our dentition. The formation of a
functional root depends on epithelial-mesenchymal interactions and integration of the root …

Reciprocal interactions between epithelial and mesenchymal tissues play a fundamental
role in the morphogenesis of teeth and regulate all aspects of tooth development. Extensive …

Tissue homeostasis requires the production of newly differentiated cells from resident adult
stem cells. Central to this process is the expansion of undifferentiated intermediates known …