Microfluidic technologies and devices for lipid nanoparticle-based RNA delivery
In 2021, mRNA vaccines against COVID-19 were approved by the Food and Drug
Administration. mRNA vaccines are important for preventing severe COVID-19 and returning …
Administration. mRNA vaccines are important for preventing severe COVID-19 and returning …
Cytosolic delivery of nucleic acids: The case of ionizable lipid nanoparticles
Ionizable lipid nanoparticles (LNPs) are the most clinically advanced nano‐delivery system
for therapeutic nucleic acids. The great effort put in the development of ionizable lipids with …
for therapeutic nucleic acids. The great effort put in the development of ionizable lipids with …
Lipid nanoparticle technology for clinical translation of siRNA therapeutics
JA Kulkarni, D Witzigmann, S Chen… - Accounts of chemical …, 2019 - ACS Publications
Conspectus Delivering nucleic acid-based therapeutics to cells is an attractive approach to
target the genetic cause of various diseases. In contrast to conventional small molecule …
target the genetic cause of various diseases. In contrast to conventional small molecule …
[HTML][HTML] A single administration of CRISPR/Cas9 lipid nanoparticles achieves robust and persistent in vivo genome editing
JD Finn, AR Smith, MC Patel, L Shaw, MR Youniss… - Cell reports, 2018 - cell.com
The development of clinically viable delivery methods presents one of the greatest
challenges in the therapeutic application of CRISPR/Cas9 mediated genome editing. Here …
challenges in the therapeutic application of CRISPR/Cas9 mediated genome editing. Here …
Lipid nanoparticle systems for enabling gene therapies
PR Cullis, MJ Hope - Molecular Therapy, 2017 - cell.com
Genetic drugs such as small interfering RNA (siRNA), mRNA, or plasmid DNA provide
potential gene therapies to treat most diseases by silencing pathological genes, expressing …
potential gene therapies to treat most diseases by silencing pathological genes, expressing …
Lipid nanoparticle technology for therapeutic gene regulation in the liver
Hereditary genetic disorders, cancer, and infectious diseases of the liver affect millions of
people around the globe and are a major public health burden. Most contemporary …
people around the globe and are a major public health burden. Most contemporary …
On the role of helper lipids in lipid nanoparticle formulations of siRNA
Onpattro, the first RNAi-based therapeutic to receive FDA approval, is enabled by a lipid
nanoparticle (LNP) system that facilitates siRNA delivery into the cytoplasm of target cells …
nanoparticle (LNP) system that facilitates siRNA delivery into the cytoplasm of target cells …
On the formation and morphology of lipid nanoparticles containing ionizable cationic lipids and siRNA
JA Kulkarni, MM Darjuan, JE Mercer, S Chen… - ACS …, 2018 - ACS Publications
Lipid nanoparticles (LNPs) containing short interfering RNA (LNP-siRNA) and optimized
ionizable cationic lipids are now clinically validated systems for silencing disease-causing …
ionizable cationic lipids are now clinically validated systems for silencing disease-causing …
[HTML][HTML] Bone-targeted bioengineered bacterial extracellular vesicles delivering siRNA to ameliorate osteoporosis
H Liu, H Zhang, S Wang, J Cui, W Weng, X Liu… - Composites Part B …, 2023 - Elsevier
Osteoporosis (OP), characterized by decreased bone mass and destruction of bone
microarchitecture, is the most common bone degenerative disease. Conventional treatments …
microarchitecture, is the most common bone degenerative disease. Conventional treatments …
Lipid nanoparticles as delivery vehicles for inhaled therapeutics
EWX Leong, R Ge - Biomedicines, 2022 - mdpi.com
Lipid nanoparticles (LNPs) have emerged as a powerful non-viral carrier for drug delivery.
With the prevalence of respiratory diseases, particularly highlighted by the current COVID-19 …
With the prevalence of respiratory diseases, particularly highlighted by the current COVID-19 …