Phosphodiesterases in heart and vessels-From Physiology to Diseases
Q Fu, Y Wang, C Yan, YK Xiang - Physiological Reviews, 2023 - journals.physiology.org
Phosphodiesterases (PDEs) are a superfamily of enzymes that hydrolyze cyclic nucleotides,
including cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate …
including cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate …
Unveiling the hidden landscape of arterial diseases at single cell resolution
CA Scipione, SJ Hyduk, CK Polenz… - Canadian Journal of …, 2023 - Elsevier
High-resolution single cell technologies have shed light on the pathogenesis of
cardiovascular diseases by enabling the discovery of novel cellular and transcriptomic …
cardiovascular diseases by enabling the discovery of novel cellular and transcriptomic …
[HTML][HTML] Transcriptome analysis reveals therapeutic potential of NAMPT in protecting against abdominal aortic aneurysm in human and mouse
Y Ouyang, Y Hong, C Mai, H Yang, Z Wu, X Gao… - Bioactive Materials, 2024 - Elsevier
Abstract Abdominal Aortic Aneurysm (AAA) is a life-threatening vascular disease
characterized by the weakening and ballooning of the abdominal aorta, which has no …
characterized by the weakening and ballooning of the abdominal aorta, which has no …
The cGAS-STING pathway in cardiovascular diseases: from basic research to clinical perspectives
C An, Z Li, Y Chen, S Huang, F Yang, Y Hu, T Xu… - Cell & Bioscience, 2024 - Springer
The cyclic guanosine monophosphate (GMP)-adenosine monophosphate (AMP) synthase-
stimulator of interferon genes (cGAS-STING) signaling pathway, an important component of …
stimulator of interferon genes (cGAS-STING) signaling pathway, an important component of …
Role of EZH2-mediated epigenetic modification on vascular smooth muscle in cardiovascular diseases: A mini-review
H Luo, Y Li, H Song, K Zhao, W Li, H Hong… - Frontiers in …, 2024 - frontiersin.org
Vascular smooth muscle cells (VSMCs) are integral to the pathophysiology of cardiovascular
diseases (CVDs). Enhancer of zeste homolog 2 (EZH2), a histone methyltransferase, plays a …
diseases (CVDs). Enhancer of zeste homolog 2 (EZH2), a histone methyltransferase, plays a …
[HTML][HTML] Sympathetic hyperinnervation drives abdominal aortic aneurysm development by promoting vascular smooth muscle cell phenotypic switching
Z Tang, J Xie, M Jin, G Wei, Z Fu, X Luo, C Li… - Journal of Advanced …, 2024 - Elsevier
Introduction Sympathetic hyperinnervation plays an important role in modulating the
vascular smooth muscle cell (VSMC) phenotype and vascular diseases, but its role in …
vascular smooth muscle cell (VSMC) phenotype and vascular diseases, but its role in …
The key role of miRNA in syndromic and sporadic forms of ascending aortic aneurysms as biomarkers and targets of novel therapeutic strategies
S Terriaca, R Monastero, A Orlandi… - Frontiers in …, 2024 - frontiersin.org
Increasing evidence shows that epigenetics also plays a key role in regulating the
pathogenetic mechanism of all types of aortic aneurysms. It is well-known that epigenetic …
pathogenetic mechanism of all types of aortic aneurysms. It is well-known that epigenetic …
Smooth muscle cell phenotypic switching occurs independent of aortic dilation in bicuspid aortic valve-associated ascending aortas
B Balint, IGL Bernstorff, T Schwab, HJ Schäfers - PloS one, 2024 - journals.plos.org
Background Bicuspid aortic valves (BAV) are frequently associated with ascending aortic
aneurysms. The etiology is incompletely understood, but genetic factors, in addition to flow …
aneurysms. The etiology is incompletely understood, but genetic factors, in addition to flow …
JMJD6 Autoantibodies as a Potential Biomarker for Inflammation-Related Diseases
BS Zhang, XM Zhang, M Ito, S Yajima… - International Journal of …, 2024 - mdpi.com
Inflammation is closely associated with cerebrovascular diseases, cardiovascular diseases,
diabetes, and cancers, and it is accompanied by the development of autoantibodies in the …
diabetes, and cancers, and it is accompanied by the development of autoantibodies in the …
Cardiac and perivascular myofibroblasts, matrifibrocytes, and immune fibrocytes in hypertension; commonalities and differences with other cardiovascular diseases
K Torimoto, K Elliott, Y Nakayama… - Cardiovascular …, 2024 - academic.oup.com
Hypertension is a major cause of cardiovascular diseases such as myocardial infarction and
stroke. Cardiovascular fibrosis occurs with hypertension and contributes to vascular …
stroke. Cardiovascular fibrosis occurs with hypertension and contributes to vascular …