The mitogen-activated extracellular signal-regulated kinase (MEK) pathway is one of the
best-characterized kinase cascades in cancer cell biology. It is triggered by either growth …

OBJECTIVE. The purpose of this article is to review cancer-and therapy-specific tumor
response assessment criteria used in clinical trials and in practice, with illustrative case …

Oncolytic viruses and active immunotherapeutics have complementary mechanisms of
action (MOA) that are both self amplifying in tumors, yet the impact of dose on subject …

BACKGROUND & AIMS: Tumor shrinkage has been considered a fundamental surrogate
efficacy measure for new cancer treatments. However, in patients treated with sorafenib for …

Background: This first-in-human, phase I clinical trial of p28 (NSC745104), a 28-amino-acid
fragment of the cupredoxin azurin, investigated the safety, tolerability, pharmacokinetics and …

Abstract Introduction. Response Evaluation Criteria in Solid Tumors, version 1.1 (RECIST
1.1), may underestimate activity and does not predict survival in patients with hepatocellular …

Objectives Dynamic contrast-enhanced ultrasound (DCE-US) has been used in single-
center studies to evaluate tumor response to antiangiogenic treatments: the change of area …

Objectives To predict tumor grade (G1 vs. G2/3), presence of distant metastasis (M+),
metastatic lymph nodes (N+), and microvascular invasion (VI) of pancreatic neuroendocrine …

Objective assessment of tumor responses and treatment results has been the basis for the
advancement of cancer therapies, and imaging plays a key role to provide a “common …

Hepatocellular carcinoma (HCC) continues to represent a major worldwide problem.
Although treatments such as resection, transplantation, and ablation may provide a chance …