Neuroinflammation is proposed as one of the mechanisms by which Alzheimer's disease
pathology, including amyloid-β plaques, leads to neuronal death and dysfunction. Increases …

The present review summarizes recently acquired data in vivo, which support a role of CNS
microglia as a source of defense cells in the CNS capable of carrying out certain immune …

Although microglia are considered to be a sensitive sensor for pathological processes in the
central nervous system, there are only a few studies about the distribution and density of …

The phenotypic differentiation of systemic macrophages that have infiltrated the central
nervous system, pericytes, perivascular macrophages, and the “real” resident microglial …

DNA methylation is a vital component of the epigenetic machinery that orchestrates changes
in multiple genes and helps regulate gene expression in all known vertebrates. We …

Immunohistochemical and histochemical staining were performed on Alzheimer's diseased
brain tissue obtained at autopsy. The iron‐regulatory proteins transferrin and ferritin as well …

A pathological hallmark of Alzheimer's disease is the senile plaque, composed of β-amyloid
fibrils, microglia, astrocytes, and dystrophic neurites. We reported previously that class A …

DNA methylation, is capable of modulating coordinate expression of large numbers of genes
across many different pathways, and may therefore warrant investigation for their potential …

Microglia are resident immune cells in the central nervous system (CNS), which are
essential for immune defence and critically contribute to neuronal functions during …

The senile plaque is one of the histopathologic changes that characterizes Alzheimer's
disease and the aging brain. The histopathology of senile plaques was studied using double …