mRNA-based cancer therapeutics
Due to the fact that mRNA technology allows the production of diverse vaccines and
treatments in a shorter time frame and with reduced expense compared to conventional …
treatments in a shorter time frame and with reduced expense compared to conventional …
mRNA vaccines manufacturing: Challenges and bottlenecks
Vaccines are one of the most important tools in public health and play an important role in
infectious diseases control. Owing to its precision, safe profile and flexible manufacturing …
infectious diseases control. Owing to its precision, safe profile and flexible manufacturing …
[HTML][HTML] mRNA vaccines in disease prevention and treatment
G Zhang, T Tang, Y Chen, X Huang… - Signal transduction and …, 2023 - nature.com
Abstract mRNA vaccines have emerged as highly effective strategies in the prophylaxis and
treatment of diseases, thanks largely although not totally to their extraordinary performance …
treatment of diseases, thanks largely although not totally to their extraordinary performance …
[HTML][HTML] T-cell-based immunotherapy of acute myeloid leukemia: current concepts and future developments
N Daver, AS Alotaibi, V Bücklein, M Subklewe - Leukemia, 2021 - nature.com
Acute myeloid leukemia (AML) is a heterogeneous disease linked to a broad spectrum of
molecular alterations, and as such, long-term disease control requires multiple therapeutic …
molecular alterations, and as such, long-term disease control requires multiple therapeutic …
[HTML][HTML] mRNA cancer vaccines: Advances, trends and challenges
Q He, H Gao, D Tan, H Zhang, J Wang - Acta Pharmaceutica Sinica B, 2022 - Elsevier
Patients exhibit good tolerance to messenger ribonucleic acid (mRNA) vaccines, and the
choice of encoded molecules is flexible and diverse. These vaccines can be engineered to …
choice of encoded molecules is flexible and diverse. These vaccines can be engineered to …
WT1 and PRAME RNA-loaded dendritic cell vaccine as maintenance therapy in de novo AML after intensive induction chemotherapy
Y Fløisand, M Remberger, I Bigalke, D Josefsen… - Leukemia, 2023 - nature.com
Intensive induction chemotherapy achieves complete remissions (CR) in> 60% of patients
with acute myeloid leukemia (AML) but overall survival (OS) is poor for relapsing patients not …
with acute myeloid leukemia (AML) but overall survival (OS) is poor for relapsing patients not …
[HTML][HTML] mRNA-based therapeutics in cancer treatment
H Sun, Y Zhang, G Wang, W Yang, Y Xu - Pharmaceutics, 2023 - mdpi.com
Over the past two decades, significant technological innovations have led to messenger
RNA (mRNA) becoming a promising option for developing prophylactic and therapeutic …
RNA (mRNA) becoming a promising option for developing prophylactic and therapeutic …
Engineered mRNA delivery systems for biomedical applications
J Wang, H Zhu, J Gan, G Liang, L Li… - Advanced …, 2024 - Wiley Online Library
Messenger RNA (mRNA)‐based therapeutic strategies have shown remarkable promise in
preventing and treating a staggering range of diseases. Optimizing the structure and …
preventing and treating a staggering range of diseases. Optimizing the structure and …
[HTML][HTML] Vaccination therapy for acute myeloid leukemia: where do we stand?
K Barbullushi, N Rampi, F Serpenti, M Sciumè, S Fabris… - Cancers, 2022 - mdpi.com
Simple Summary Immunotherapy is changing the therapeutic landscape of many
hematologic diseases. Nevertheless, in acute myeloid leukemia (AML) the anti CD33 …
hematologic diseases. Nevertheless, in acute myeloid leukemia (AML) the anti CD33 …
[HTML][HTML] The ins and outs of messenger RNA electroporation for physical gene delivery in immune cell-based therapy
Messenger RNA (mRNA) electroporation is a powerful tool for transient genetic modification
of cells. This non-viral method of genetic engineering has been widely used in …
of cells. This non-viral method of genetic engineering has been widely used in …