mRNA-based cancer therapeutics

C Liu, Q Shi, X Huang, S Koo, N Kong, W Tao - Nature Reviews Cancer, 2023 - nature.com
Due to the fact that mRNA technology allows the production of diverse vaccines and
treatments in a shorter time frame and with reduced expense compared to conventional …

mRNA vaccines manufacturing: Challenges and bottlenecks

SS Rosa, DMF Prazeres, AM Azevedo, MPC Marques - Vaccine, 2021 - Elsevier
Vaccines are one of the most important tools in public health and play an important role in
infectious diseases control. Owing to its precision, safe profile and flexible manufacturing …

[HTML][HTML] mRNA vaccines in disease prevention and treatment

G Zhang, T Tang, Y Chen, X Huang… - Signal transduction and …, 2023 - nature.com
Abstract mRNA vaccines have emerged as highly effective strategies in the prophylaxis and
treatment of diseases, thanks largely although not totally to their extraordinary performance …

[HTML][HTML] T-cell-based immunotherapy of acute myeloid leukemia: current concepts and future developments

N Daver, AS Alotaibi, V Bücklein, M Subklewe - Leukemia, 2021 - nature.com
Acute myeloid leukemia (AML) is a heterogeneous disease linked to a broad spectrum of
molecular alterations, and as such, long-term disease control requires multiple therapeutic …

[HTML][HTML] mRNA cancer vaccines: Advances, trends and challenges

Q He, H Gao, D Tan, H Zhang, J Wang - Acta Pharmaceutica Sinica B, 2022 - Elsevier
Patients exhibit good tolerance to messenger ribonucleic acid (mRNA) vaccines, and the
choice of encoded molecules is flexible and diverse. These vaccines can be engineered to …

WT1 and PRAME RNA-loaded dendritic cell vaccine as maintenance therapy in de novo AML after intensive induction chemotherapy

Y Fløisand, M Remberger, I Bigalke, D Josefsen… - Leukemia, 2023 - nature.com
Intensive induction chemotherapy achieves complete remissions (CR) in> 60% of patients
with acute myeloid leukemia (AML) but overall survival (OS) is poor for relapsing patients not …

[HTML][HTML] mRNA-based therapeutics in cancer treatment

H Sun, Y Zhang, G Wang, W Yang, Y Xu - Pharmaceutics, 2023 - mdpi.com
Over the past two decades, significant technological innovations have led to messenger
RNA (mRNA) becoming a promising option for developing prophylactic and therapeutic …

Engineered mRNA delivery systems for biomedical applications

J Wang, H Zhu, J Gan, G Liang, L Li… - Advanced …, 2024 - Wiley Online Library
Messenger RNA (mRNA)‐based therapeutic strategies have shown remarkable promise in
preventing and treating a staggering range of diseases. Optimizing the structure and …

[HTML][HTML] Vaccination therapy for acute myeloid leukemia: where do we stand?

K Barbullushi, N Rampi, F Serpenti, M Sciumè, S Fabris… - Cancers, 2022 - mdpi.com
Simple Summary Immunotherapy is changing the therapeutic landscape of many
hematologic diseases. Nevertheless, in acute myeloid leukemia (AML) the anti CD33 …

[HTML][HTML] The ins and outs of messenger RNA electroporation for physical gene delivery in immune cell-based therapy

D Campillo-Davo, M De Laere, G Roex, M Versteven… - Pharmaceutics, 2021 - mdpi.com
Messenger RNA (mRNA) electroporation is a powerful tool for transient genetic modification
of cells. This non-viral method of genetic engineering has been widely used in …