Stress and the microbiota–gut–brain axis in visceral pain: relevance to irritable bowel syndrome

RD Moloney, AC Johnson… - CNS neuroscience & …, 2016 - Wiley Online Library
Visceral pain is a global term used to describe pain originating from the internal organs of
the body, which affects a significant proportion of the population and is a common feature of …

Neuroplasticity and dysfunction after gastrointestinal inflammation

SM Brierley, DR Linden - Nature reviews Gastroenterology & …, 2014 - nature.com
The gastrointestinal tract is innervated by several distinct populations of neurons, whose cell
bodies either reside within (intrinsic) or outside (extrinsic) the gastrointestinal wall. Normally …

Stress-induced visceral pain: toward animal models of irritable-bowel syndrome and associated comorbidities

RD Moloney, SM O'Mahony, TG Dinan… - Frontiers in …, 2015 - frontiersin.org
Visceral pain is a global term used to describe pain originating from the internal organs,
which is distinct from somatic pain. It is a hallmark of functional gastrointestinal disorders …

Stress and visceral pain: from animal models to clinical therapies

M Larauche, A Mulak, Y Taché - Experimental neurology, 2012 - Elsevier
Epidemiological studies have implicated stress (psychosocial and physical) as a trigger of
first onset or exacerbation of irritable bowel syndrome (IBS) symptoms of which visceral pain …

Stress-induced corticotropin-releasing hormone-mediated NLRP6 inflammasome inhibition and transmissible enteritis in mice

Y Sun, M Zhang, CC Chen, M Gillilland III, X Sun… - Gastroenterology, 2013 - Elsevier
BACKGROUND & AIMS: Stress alters brain–gut interactions and could exacerbate intestinal
disorders, including irritable bowel syndrome. Alterations in the intestinal microbiota have …

Localization of nesfatin-1 neurons in the mouse brain and functional implication

M Goebel-Stengel, L Wang, A Stengel, Y Taché - Brain research, 2011 - Elsevier
Nesfatin-1 reduces food intake when injected centrally in rodents. We recently described
wide distribution of nucleobindin2 (NUCB2)/nesfatin-1 immunoreactivity in rat brain …

Stress and antibiotics alter luminal and wall‐adhered microbiota and enhance the local expression of visceral sensory‐related systems in mice

M Aguilera, P Vergara… - Neurogastroenterology & …, 2013 - Wiley Online Library
Background Stress leads to altered gastrointestinal neuro‐immune responses. We
characterized the interaction between stress and gut commensal microbiota and their role …

Visceral inflammation and immune activation stress the brain

P Holzer, A Farzi, AM Hassan, G Zenz, A Jačan… - Frontiers in …, 2017 - frontiersin.org
Stress refers to a dynamic process in which the homeostasis of an organism is challenged,
the outcome depending on the type, severity, and duration of stressors involved, the stress …

Animal models of gastrointestinal and liver diseases. Animal models of visceral pain: pathophysiology, translational relevance, and challenges

B Greenwood-Van Meerveld… - American Journal …, 2015 - journals.physiology.org
Visceral pain describes pain emanating from the thoracic, pelvic, or abdominal organs. In
contrast to somatic pain, visceral pain is generally vague, poorly localized, and …

Early-life stress induces visceral hypersensitivity in mice

RD Moloney, OF O'Leary, D Felice, B Bettler… - Neuroscience …, 2012 - Elsevier
Early-life stress is a risk factor for irritable bowel syndrome (IBS), a common and debilitating
functional gastrointestinal disorder that is often co-morbid with stress-related psychiatric …