Fibronectin type III domain-based fusion proteins

A Chilkoti, M Manzari, M Fevre - US Patent 10,385,115, 2019 - Google Patents
Provided herein are fusion proteins including at least one binding polypeptide and at least
one unstructured polypeptide. The fusion protein may further include at least one linker …

Order and disorder as a design principle for stimuli-responsive biopolymer networks

A Chilkoti, S Roberts - US Patent 11,680,083, 2023 - Google Patents
SBUJHOSQTJFQJX-NOAMYHISSA-N kanamycin Chemical compound O [C@@ H] 1 [C@@
H](O)[C@ H](O)[C@@ H](CN) O [C@@ H] 1O [C@ H] 1 [C@ H](O)[C@@ H](O [C@@ H] 2 …

Polymer conjugates having reduced antigenicity and methods of using the same

A Chilkoti, Y Qi, MS Hershfield, NJ Ganson - US Patent 10,364,451, 2019 - Google Patents
Disclosed herein are compositions and methods for reducing the antigenicity of molecules.
The antigenicity of a molecule may be reduced or eliminated by conjugating at least one …

Compositions and methods for biocontainment of microorganisms

FJ Isaacs, R Gallagher, J Patel, A Rovner - US Patent 11,408,007, 2022 - Google Patents
5,362,646 A 5,464,758 A 5,589,362 A 5,650,298 A 5,654,168 A 5,789,156 A 5,814,618 A
5,888,981 A 5,922,927 A 6,004,941 A 6,087,166 A 6,136,954 A 6,242,667 B1 6,252,136 B1 …

Amphiphilic polynucleotides

A Chilkoti, S Zauscher, L Tang… - US Patent 11,965,164, 2024 - Google Patents
Compositions and methods disclosed herein can help provide improved delivery of non-
natural therapeutic nucleotides for the treatment of diseases such as cancer. An example …

Unstructured non-repetitive polypeptides having lcst behavior

A Chilkoti, T Nicholas, G Kelly - US Patent 12,084,480, 2024 - Google Patents
Described herein are unstructured polypeptides lacking any discernible repeat motif. Also
described herein are fusion proteins including at least one of the unstructured polypeptides …

Dual agonist fusion proteins

A Chilkoti, C Gilroy - US Patent 11,649,275, 2023 - Google Patents
US11649275B2 - Dual agonist fusion proteins - Google Patents US11649275B2 - Dual
agonist fusion proteins - Google Patents Dual agonist fusion proteins Download PDF Info …

Recombinant production of hybrid lipid-biopolymer materials that self-assemble and encapsulate agents

A Chilkoti, K Luginbuhl, D Mozhdehi - US Patent 11,554,097, 2023 - Google Patents
A61K31/704—Compounds having saccharide radicals attached to non-saccharide
compounds by glycosidic linkages attached to a carbocyclic compound, eg phloridzin …

Engineering organisms resistant to viruses and horizontally transferred genetic elements

F Isaacs, N Ma, J Rinehart, C Hemez - US Patent 11,149,280, 2021 - Google Patents
Organisms resistant to horizontal gene transfer (HGT), and compositions and methods of
use thereof are provided. The organisms are typically genomically recoded organisms …

Surfaces having reduced non-specific binding and antigenicity

A Hucknall, A Chilkoti, D Joh, NJ Ganson, Y Qi… - US Patent …, 2023 - Google Patents
Disclosed herein are compositions and methods for reducing the antigenicity of molecules.
The antigenicity of a molecule may be reduced or eliminated by conjugating at least one …