Advanced glycation end-products (AGEs): Formation, chemistry, classification, receptors, and diseases related to AGEs

A Twarda-Clapa, A Olczak, AM Białkowska… - Cells, 2022 - mdpi.com
Advanced glycation end-products (AGEs) constitute a non-homogenous, chemically diverse
group of compounds formed either exogeneously or endogeneously on the course of …

Molecular mechanisms of ROS production and oxidative stress in diabetes

P Newsholme, VF Cruzat, KN Keane… - Biochemical …, 2016 - portlandpress.com
Oxidative stress and chronic inflammation are known to be associated with the development
of metabolic diseases, including diabetes. Oxidative stress, an imbalance between oxidative …

RAGE regulation and signaling in inflammation and beyond

K Kierdorf, G Fritz - Journal of leukocyte biology, 2013 - academic.oup.com
ABSTRACT RAGE is a key molecule in the onset and sustainment of the inflammatory
response. New studies indicate that RAGE might represent a new link between the innate …

Receptor for AGEs (RAGE) as mediator of NF-kB pathway activation in neuroinflammation and oxidative stress

JC Tobon-Velasco, E Cuevas… - CNS & Neurological …, 2014 - ingentaconnect.com
Recently, it has been proposed that the receptor for advanced glycation end-products
(RAGE) plays a crucial role in damaging cellular processes, such as neuroinflammation …

Advanced glycation end products and their effect on vascular complications in type 2 diabetes mellitus

J Lee, JS Yun, SH Ko - Nutrients, 2022 - mdpi.com
Diabetes is well established as a chronic disease with a high health burden due to mortality
or morbidity from the final outcomes of vascular complications. An increased duration of …

A role for advanced glycation end products in molecular ageing

K Zgutka, M Tkacz, P Tomasiak… - International journal of …, 2023 - mdpi.com
Ageing is a composite process that involves numerous changes at the cellular, tissue, organ
and whole-body levels. These changes result in decreased functioning of the organism and …

Receptor for advanced glycation end products acts as a fuel to colorectal cancer development

F Azizian-Farsani, N Abedpoor… - Frontiers in …, 2020 - frontiersin.org
Receptor for advanced glycation end-products (RAGE) is a multiligand binding and single-
pass transmembrane protein taken in diverse chronic inflammatory conditions. RAGE …

Role of RAGE in the Pathogenesis of Neurological Disorders

J Juranek, K Mukherjee, B Kordas, M Załęcki… - Neuroscience …, 2022 - Springer
This review reflects upon our own as well as other investigators' studies on the role of
receptor for advanced glycation end-products (RAGE), bringing up the latest information on …

[HTML][HTML] RAGE mediates S100A4-induced cell motility via MAPK/ERK and hypoxia signaling and is a prognostic biomarker for human colorectal cancer metastasis

M Dahlmann, A Okhrimenko, P Marcinkowski… - Oncotarget, 2014 - ncbi.nlm.nih.gov
Survival of colorectal cancer patients is strongly dependent on development of distant
metastases. S100A4 is a prognostic biomarker and inducer for colorectal cancer metastasis …

Linking glycation and glycosylation with inflammation and mitochondrial dysfunction in Parkinson's disease

PAQ Videira, M Castro-Caldas - Frontiers in neuroscience, 2018 - frontiersin.org
Parkinson's disease (PD) is the second most common neurodegenerative disorder, affecting
about 6.3 million people worldwide. PD is characterized by the progressive degeneration of …