There is a large gap between the deep understanding of mechanisms driving tumour growth
and the reasons why patients ultimately die of cancer. It is now appreciated that interactions …

Cancer metastasis is one of the leading causes of death worldwide, motivating research into
identifying new methods of preventing cancer metastasis. Recently there has been …

A central question in mechanobiology is how mechanical forces acting in or on cells are
transmitted to mechanically-gated PIEZO channels that convert these forces into …

Tissue regeneration after injury requires coordinated regulation of stem cell activation,
division, and daughter cell differentiation, processes that are increasingly well understood in …

One of the strategies used by cells to degrade and remodel the extracellular matrix (ECM) is
based on invadosomes, actin-based force-producing cell–ECM contacts that function in …

Cancer metastasis causes over 90% of cancer patient fatalities. Poor prognosis is
determined by tumor type, the tumor microenvironment (TME), organ-specific biology, and …

Morphogenetic programs coordinate cell signaling and mechanical interactions to shape
organs. In systems and synthetic biology, a key challenge is determining optimal cellular …

Germ cells possess the Piwi-interacting RNA pathway to repress transposable elements and
maintain genome stability across generations. Transposable element mobilization in …

Many tumors recapitulate the developmental and differentiation program of their tissue of
origin, a basis for tumor cell heterogeneity. Although stem-cell-like tumor cells are well …

Three-dimensional (3D) in vitro models are essential in cancer research, but they often
neglect physical forces. In our study, we combined patient-derived tumor organoids with a …