Nearly 30 years ago, certain small, relatively nontoxic peptides were discovered to be
capable of traversing the cell membrane. These cell-penetrating peptides, as they are now …

ABSTRACT Introduction: Cell penetrating peptides (CPPs) known as protein translocation
domains (PTD), membrane translocating sequences (MTS), or Trojan peptides (TP) are able …

In the last 20 years, an increasing number of studies have been reported on membrane
active peptides. These peptides exert their biological activity by interacting with the cell …

Unique characteristics, such as nontoxicity and rapid cellular internalization, allow the cell-
penetrating peptides (CPPs) to transport hydrophilic macromolecules into cells, thus …

Central nervous system (CNS) diseases are among the most difficult to treat, mainly
because the vast majority of the drugs fail to cross the blood-brain barrier (BBB) or to reach …

The failure to treat everyday bacterial infections is a current threat as pathogens are finding
new ways to thwart antibiotics through mechanisms of resistance and intracellular refuge …

After the first seed concept introduced in the 18th century, different disciplines have
attributed different names to dual-functional molecules depending on their application …

Health is fundamental for the development of individuals and evolution of species. In that
sense, for human societies is relevant to understand how the human body has developed …

Membrane interaction constitutes to be an essential parameter in the mode of action of
entities such as proteins, as well as cell-penetrating and antimicrobial peptides, resulting in …

Designing drug delivery vehicles using cell-penetrating peptides is a hot area of research in
the field of medicine. In the past, number of in silico methods have been developed for …