Thioredoxin and thioredoxin target proteins: from molecular mechanisms to functional significance
The thioredoxin (Trx) system is one of the central antioxidant systems in mammalian cells,
maintaining a reducing environment by catalyzing electron flux from nicotinamide adenine …
maintaining a reducing environment by catalyzing electron flux from nicotinamide adenine …
[HTML][HTML] Thioredoxin-interacting protein (TXNIP) with focus on brain and neurodegenerative diseases
H Tsubaki, I Tooyama, DG Walker - International journal of molecular …, 2020 - mdpi.com
The development of new therapeutic approaches to diseases relies on the identification of
key molecular targets involved in amplifying disease processes. One such molecule is …
key molecular targets involved in amplifying disease processes. One such molecule is …
[HTML][HTML] AMPK-dependent degradation of TXNIP upon energy stress leads to enhanced glucose uptake via GLUT1
Thioredoxin-interacting protein (TXNIP) is an α-arrestin family protein that is induced in
response to glucose elevation. It has been shown to provide a negative feedback loop to …
response to glucose elevation. It has been shown to provide a negative feedback loop to …
[HTML][HTML] Thioredoxin/Txnip: redoxisome, as a redox switch for the pathogenesis of diseases
During the past few decades, it has been widely recognized that Reduction-Oxidation
(redox) responses occurring at the intra-and extra-cellular levels are one of most important …
(redox) responses occurring at the intra-and extra-cellular levels are one of most important …
TXNIP in metabolic regulation: physiological role and therapeutic outlook
N Mohammad Alhawiti, S Al Mahri… - Current drug …, 2017 - ingentaconnect.com
Background & Objective: Thioredoxin-interacting protein (TXNIP) also known as thioredoxin
binding protein-2 is a ubiquitously expressed protein that interacts and negatively regulates …
binding protein-2 is a ubiquitously expressed protein that interacts and negatively regulates …
[HTML][HTML] Phosphorylation of TXNIP by AKT mediates acute influx of glucose in response to insulin
AN Waldhart, H Dykstra, AS Peck, EA Boguslawski… - Cell reports, 2017 - cell.com
Growth factors, such as insulin, can induce both acute and long-term glucose uptake into
cells. Apart from the rapid, insulin-induced fusion of glucose transporter (GLUT) 4 storage …
cells. Apart from the rapid, insulin-induced fusion of glucose transporter (GLUT) 4 storage …
Epigenomic profiling reveals an association between persistence of DNA methylation and metabolic memory in the DCCT/EDIC type 1 diabetes cohort
Z Chen, F Miao, AD Paterson… - Proceedings of the …, 2016 - National Acad Sciences
We examined whether persistence of epigenetic DNA methylation (DNA-me) alterations at
specific loci over two different time points in people with diabetes are associated with …
specific loci over two different time points in people with diabetes are associated with …
Role of iron in carcinogenesis: cancer as a ferrotoxic disease
S Toyokuni - Cancer science, 2009 - Wiley Online Library
Iron is abundant universally. During the evolutionary processes, humans have selected iron
as a carrier of oxygen inside the body. However, iron works as a double‐edged sword, and …
as a carrier of oxygen inside the body. However, iron works as a double‐edged sword, and …
The thioredoxin system as a therapeutic target in human health and disease
DFD Mahmood, A Abderrazak, K El Hadri… - Antioxidants & redox …, 2013 - liebertpub.com
The thioredoxin (Trx) system comprises Trx, truncated Trx (Trx-80), Trx reductase, and
NADPH, besides a natural Trx inhibitor, the thioredoxin-interacting protein (TXNIP). This …
NADPH, besides a natural Trx inhibitor, the thioredoxin-interacting protein (TXNIP). This …
[HTML][HTML] TXNIP/TBP-2: a master regulator for glucose homeostasis
E Yoshihara - Antioxidants, 2020 - mdpi.com
Identification of thioredoxin binding protein-2 (TBP-2), which is currently known as
thioredoxin interacting protein (TXNIP), as an important binding partner for thioredoxin (TRX) …
thioredoxin interacting protein (TXNIP), as an important binding partner for thioredoxin (TRX) …