The thioredoxin (Trx) system is one of the central antioxidant systems in mammalian cells,
maintaining a reducing environment by catalyzing electron flux from nicotinamide adenine …

The development of new therapeutic approaches to diseases relies on the identification of
key molecular targets involved in amplifying disease processes. One such molecule is …

Thioredoxin-interacting protein (TXNIP) is an α-arrestin family protein that is induced in
response to glucose elevation. It has been shown to provide a negative feedback loop to …

During the past few decades, it has been widely recognized that Reduction-Oxidation
(redox) responses occurring at the intra-and extra-cellular levels are one of most important …

Background & Objective: Thioredoxin-interacting protein (TXNIP) also known as thioredoxin
binding protein-2 is a ubiquitously expressed protein that interacts and negatively regulates …

Growth factors, such as insulin, can induce both acute and long-term glucose uptake into
cells. Apart from the rapid, insulin-induced fusion of glucose transporter (GLUT) 4 storage …

We examined whether persistence of epigenetic DNA methylation (DNA-me) alterations at
specific loci over two different time points in people with diabetes are associated with …

Iron is abundant universally. During the evolutionary processes, humans have selected iron
as a carrier of oxygen inside the body. However, iron works as a double‐edged sword, and …

The thioredoxin (Trx) system comprises Trx, truncated Trx (Trx-80), Trx reductase, and
NADPH, besides a natural Trx inhibitor, the thioredoxin-interacting protein (TXNIP). This …

Identification of thioredoxin binding protein-2 (TBP-2), which is currently known as
thioredoxin interacting protein (TXNIP), as an important binding partner for thioredoxin (TRX) …