The cytoskeleton and its components—actin, microtubules and intermediate filaments—
have been studied for decades, and multiple roles of the individual cytoskeletal …

Fuelled by ATP hydrolysis, dyneins generate force and movement on microtubules in a
wealth of biological processes, including ciliary beating, cell division and intracellular …

The centrosome acts as the main microtubule-nucleating organelle in animal cells and plays
a critical role in mitotic spindle orientation and in genome stability. Yet, despite its central …

Fertilization triggers a complex cellular programme that transforms two highly specialized
meiotic germ cells, the oocyte and the sperm, into a totipotent mitotic embryo. Linkages …

Dynein at the cortex contributes to microtubule-based positioning processes such as spindle
positioning during embryonic cell division and centrosome positioning during fibroblast …

© 2012 Marshall et al; licensee BioMed Central Ltd. This is an Open Access article
distributed under the terms of the Creative Commons Attribution License (http …

Polarity establishment, asymmetric division, and acquisition of cell fates are critical steps
during earlydevelopment. In this review, we discuss processes that set up the embryonic …

Correct spindle positioning is fundamental for proper cell division during development and
in stem cell lineages. Dynein and an evolutionarily conserved ternary complex (nuclear …

Accurate positioning of spindles is essential for asymmetric mitotic and meiotic cell divisions
that are crucial for animal development and oocyte maturation, respectively. The …

Correct positioning of the spindle governs placement of the cytokinesis furrow and thus
plays a crucial role in the partitioning of fate determinants and the disposition of daughter …