Zebrafish are increasingly being utilized as a model system to investigate the function of the
growing list of risk genes associated with neurodevelopmental disorders. This is due in large …

Membrane trafficking pathways are essential for the viability and growth of cells, and play a
major role in the interaction of cells with their environment. In this At a Glance article and …

For the past few years there has been an exponential increase in the use of animal models
to confirm the pathogenicity of candidate disease-causing genetic variants found in patients …

Neurodevelopmental disorders (NDDs) caused by aberrant brain growth and development
are life-long, debilitating illnesses that markedly impair the quality of life. Animal models are …

The movement of proteins between cellular compartments requires the orchestrated actions
of many factors including Rab family GTPases, Soluble NSF Attachment protein REceptors …

The highly evolutionarily conserved transport protein particle (TRAPP) complexes (TRAPP II
and III) perform fundamental roles in subcellular trafficking pathways. Here we identified …

Genetic mutations in the gene encoding transport protein particle complex 9 (trappc9), a
subunit of TRAPP that acts as a guanine nucleotide exchange factor for rab proteins, cause …

Membrane and secretory proteins are essential for almost every aspect of cellular function.
These proteins are incorporated into ER-derived carriers and transported to the Golgi before …

Our understanding of the genetic aetiology of paediatric epilepsies has grown substantially
over the last decade. However, in order to translate improved diagnostics to personalised …

The Golgi apparatus (GA) is involved in a whole spectrum of activities, from lipid
biosynthesis and membrane secretion to the posttranslational processing and trafficking of …