The Complement System: A Prey of Trypanosoma cruzi
KCF Lidani, L Bavia, AR Ambrosio… - Frontiers in …, 2017 - frontiersin.org
Trypanosoma cruzi is a protozoan parasite known to cause Chagas disease (CD), a
neglected sickness that affects around 6–8 million people worldwide. Originally, CD was …
neglected sickness that affects around 6–8 million people worldwide. Originally, CD was …
The role of the complement cascade in ischemia/reperfusion injury: implications for neuroprotection
AL D'Ambrosio, DJ Pinsky, ES Connolly - Molecular medicine, 2001 - Springer
Background The complement cascade plays a deleterious role in multiple models of
ischemia/reperfusion (I/R) injury, including stroke. Investigation of the complement cascade …
ischemia/reperfusion (I/R) injury, including stroke. Investigation of the complement cascade …
Quantitative characterization of the activation steps of mannan-binding lectin (MBL)-associated serine proteases (MASPs) points to the central role of MASP-1 in the …
Mannan-binding lectin (MBL)-associated serine proteases, MASP-1 and MASP-2, have
been thought to autoactivate when MBL/ficolin· MASP complexes bind to pathogens …
been thought to autoactivate when MBL/ficolin· MASP complexes bind to pathogens …
The structure of MBL-associated serine protease-2 reveals that identical substrate specificities of C1s and MASP-2 are realized through different sets of enzyme …
A family of serine proteases mediates the proteolytic cascades of several defense
mechanisms in vertebrates, such as the complement system, blood coagulation and …
mechanisms in vertebrates, such as the complement system, blood coagulation and …
The role of the individual domains in the structure and function of the catalytic region of a modular serine protease, C1r
The first enzymatic event in the classical pathway of complement activation is autoactivation
of the C1r subcomponent of the C1 complex. Activated C1r then cleaves and activates …
of the C1r subcomponent of the C1 complex. Activated C1r then cleaves and activates …
Structure and function of complement activating enzyme complexes C1 and MBL-MASPs
The complement system is a major effector arm of the immune defense contributing to the
destruction of invading pathogens. There are three possible routes of complement cascade …
destruction of invading pathogens. There are three possible routes of complement cascade …
The initiating proteases of the complement system: controlling the cleavage
RC Duncan, LC Wijeyewickrema, RN Pike - Biochimie, 2008 - Elsevier
The complement system is a vital component of the host immune system, but when
dysregulated, can also cause disease. The system is activated by three pathways: classical …
dysregulated, can also cause disease. The system is activated by three pathways: classical …
Folded recombinant catalytic fragments of multidomain serine proteases, preparation and uses thereof
The invention relates to unglycosylated folded C-terminal fragments of a multidomain serine
protease of the complement cascade obtainable by expression in a bacterial host, wherein …
protease of the complement cascade obtainable by expression in a bacterial host, wherein …
Trypanosoma cruzi infection: Mechanisms of evasion of immune response
AC Reyes, JLR Encina - Biology of Trypanosoma cruzi, 2019 - books.google.com
Trypanosoma cruzi has a complex life cycle that involves a vertebrate as well as an
invertebrate host. In this, last two stages are present: trypomastigotes, the flagellated and …
invertebrate host. In this, last two stages are present: trypomastigotes, the flagellated and …
The initiation complexes of the classical and lectin pathways
Various antigen structures initiate the classical and the lectin pathways of complement
activation. Multidomain modular proteases (C1r, C1s and MASPs) are involved in the …
activation. Multidomain modular proteases (C1r, C1s and MASPs) are involved in the …