Bilirubin in clinical practice: a review

J Fevery - Liver International, 2008 - Wiley Online Library
Bilirubin is an endogenous compound that can be toxic under certain conditions but, on the
other hand, mild unconjugated hyperbilirubinaemia might protect against cardiovascular …

Looking to the horizon: the role of bilirubin in the development and prevention of age-related chronic diseases

KH Wagner, M Wallner, C Mölzer, S Gazzin… - Clinical …, 2015 - portlandpress.com
Bilirubin, the principal tetrapyrrole, bile pigment and catabolite of haem, is an emerging
biomarker of disease resistance, which may be related to several recently documented …

The genetic basis of the reduced expression of bilirubin UDP-glucuronosyltransferase 1 in Gilbert's syndrome

PJ Bosma, JR Chowdhury, C Bakker… - … England Journal of …, 1995 - Mass Medical Soc
Background People with Gilbert's syndrome have mild, chronic unconjugated
hyperbilirubinemia in the absence of liver disease or overt hemolysis. Hepatic …

Serum bilirubin levels in the US population: gender effect and inverse correlation with colorectal cancer

SD Zucker, PS Horn, KE Sherman - Hepatology, 2004 - journals.lww.com
Bilirubin, the primary end product of heme catabolism, is a key marker of liver and
hematological disorders, and important cytoprotective properties have been ascribed to this …

Circulating bilirubin levels and risk of colorectal cancer: serological and Mendelian randomization analyses

N Seyed Khoei, M Jenab, N Murphy, BL Banbury… - BMC medicine, 2020 - Springer
Background Bilirubin, a byproduct of hemoglobin breakdown and purported anti-oxidant, is
thought to be cancer preventive. We conducted complementary serological and Mendelian …

Loci from a genome-wide analysis of bilirubin levels are associated with gallstone risk and composition

S Buch, C Schafmayer, H Völzke, M Seeger, JF Miquel… - Gastroenterology, 2010 - Elsevier
BACKGROUND & AIMS: Genome-wide association studies have mapped loci that are
associated with serum levels of bilirubin. Bilirubin is a major component of gallstones so we …

[HTML][HTML] Serum bilirubin levels are inversely associated with nonalcoholic fatty liver disease

MS Kwak, D Kim, GE Chung, SJ Kang… - Clinical and …, 2012 - ncbi.nlm.nih.gov
Methods A cross-sectional study of 17,348 subjects undergoing a routine health check-up
was conducted. Subjects positive for hepatitis B or hepatitis C virus, or with other hepatitis …

[HTML][HTML] Unconjugated hyperbilirubinemia

A Singh, T Koritala, I Jialal - 2019 - europepmc.org
Objectives: Describe the physiology of bilirubin metabolism. Explain how to differentiate
unconjugated hyperbilirubinemia from conjugated hyperbilirubinemia. Identify the several …

Overview of Gilbert's syndrome

D King, MJ Armstrong - Drug and therapeutics bulletin, 2019 - dtb.bmj.com
Gilbert's syndrome (GS) is a benign hereditary disorder of bilirubin conjugation resulting in
an isolated, elevated blood level of unconjugated bilirubin. 1 GS affects 2%–10% of the …

[HTML][HTML] Association between bilirubin and risk of Non-Alcoholic Fatty Liver Disease based on a prospective cohort study

J Tian, R Zhong, C Liu, Y Tang, J Gong, J Chang… - Scientific reports, 2016 - nature.com
The study aimed to assess the association between total, direct and indirect bilirubin and
nonalcoholic fatty live disease (NAFLD) risk given its high prevalence and serious clinical …