Ferulic acid, a kind of phenolic substance widely existing in plants, is an important active
component of many traditional Chinese medicines. So far, it has been proved that ferulic …

Multidrug resistance (MDR) is the dominant challenge in the failure of chemotherapy in
cancers. Phosphatidylinositol 3-kinase (PI3K) is a lipid kinase that spreads intracellular …

Ischemic stroke is one of the major causes of morbidity and mortality, affecting millions of
people worldwide. Inevitably, the interruption of cerebral blood supply after ischemia may …

Shikonin is the major bioactive component extracted from the roots of Lithospermum
erythrorhizon which is also known as “Zicao” in Traditional Chinese Medicine (TCM). Recent …

Autophagy is a self-eating cellular catabolic pathway, through which long-lived proteins,
damaged organelles and misfolded proteins are degraded and recycled for the …

Background/Aims: Reperfusion after an ischaemic insult might cause infarct extension.
Mesenchymal stem cell (MSC)-derived exosomes could attenuate myocardial remodelling in …

In the last decade, the endoplasmic reticulum (ER) has emerged as a central organelle
regulating the core mitochondrial apoptosis pathway. At the ER membrane, a variety of …

Inhibitors of apoptosis (IAPs) are a family of proteins that play a significant role in the control
of programmed cell death (PCD). PCD is essential to maintain healthy cell turnover within …

Bax and its homolog Bak are key regulators of the mitochondrial pathway of apoptosis. On
cell stress Bax and Bak accumulate at distinct foci on the mitochondrial surface where they …

Colorectal neoplasia differentially expressed (CRNDE) is the most upregulated long
noncoding RNA (lncRNA) in glioma. Herein, the function and potential molecular …