Parkinson's disease (PD) is a common neurodegenerative disease that is characterized by
the degeneration of dopaminergic neurons in the substantia nigra pars compacta …

Dopamine is a key neurotransmitter that induces critical effects in the nervous system and in
many peripheral organs, via 5 dopamine receptors (DRs): D1R–D5R. Dopamine also …

Abstract Treatment with amantadine (AMA), an N-methyl-D-aspartate (NMDA) receptor
antagonist and antidepressant drug, increased the antidepressant activity of subsequent …

Considerable attention has been paid to a possible role of immunological dysregulation in
the pathogenesis of depression. It has been reported that combined administration of …

The activation of cell-mediated immunity and the hypothalamic–pituitary–adrenal axis may
play a role in the pathophysiology of depression, especially a treatment-resistant one, and …

The antiviral drug amantadine, that is effective in idiopathic Parkinson's disease (PD), may
affect the composition and function of peripheral blood lymphocytes. In an explorative study …

Parkinson's disease (PD) is a disorder that destroys neurons in the extrapyramidal
dopaminergic pathway in the brain. In the world, the number of patients with PD is 10 million …

The present in vitro investigations on amantadine (AmTd) and its isomer 2-
aminoadamantane (2-NH 2-Adam), and the corresponding analogs, 1-nitroadamantane (1 …

Ribavirin wurde als eines der ältesten Virostatika zuletzt va zur Therapie der chronischen
Hepatitis C verwendet. Sein genauer Wirkungsmechanismus ist aber unbekannt. Es scheint …

Background Amantadine has been reported to have a neuroprotective effect, and it is
therefore expected to have further clinical application. Aim In this study, we examined the …