[HTML][HTML] Nanomedicine and graphene-based materials: advanced technologies for potential treatments of diseases in the developing nervous system

G Cellot, A Franceschi Biagioni, L Ballerini - Pediatric Research, 2022 - nature.com
The interest in graphene-based nanomaterials (GBNs) application in nanomedicine, in
particular in neurology, steadily increased in the last decades. GBNs peculiar physical …

Engineering advanced nanomedicines against central nervous system diseases

S Shi, H Ren, Y Xie, M Yu, Y Chen, L Yang - Materials Today, 2023 - Elsevier
Despite the impressive strides in the research community, numerous obstacles pose marked
challenges in the treatment of central nervous system (CNS) disorders. The limitations of …

Graphene oxide nanosheets reduce astrocyte reactivity to inflammation and ameliorate experimental autoimmune encephalomyelitis

G Di Mauro, R Amoriello, N Lozano, A Carnasciali… - ACS …, 2023 - ACS Publications
In neuroinflammation, astrocytes play multifaceted roles that regulate the neuronal
environment. Astrocytes sense and respond to pro-inflammatory cytokines (CKs) and, by a …

[HTML][HTML] The dual action of glioma-derived exosomes on neuronal activity: synchronization and disruption of synchrony

R Spelat, N Jihua, CA Sánchez Triviño, S Pifferi… - Cell Death & …, 2022 - nature.com
Seizures represent a frequent symptom in gliomas and significantly impact patient morbidity
and quality of life. Although the pathogenesis of tumor-related seizures is not fully …

Bonding of neuropeptide Y on graphene oxide for drug delivery applications to the central nervous system

G Cellot, L Jacquemin, G Reina… - ACS Applied Nano …, 2022 - ACS Publications
Nanoscale graphene-based materials (GBMs) enable targeting subcellular structures of the
nervous system, a feature crucial for the successful engineering of alternative nanocarriers …

[HTML][HTML] Graphene oxide prevents lateral amygdala dysfunctional synaptic plasticity and reverts long lasting anxiety behavior in rats

AF Biagioni, G Cellot, E Pati, N Lozano, B Ballesteros… - Biomaterials, 2021 - Elsevier
Engineered small graphene oxide (s-GO) sheets were previously shown to reversibly down-
regulate glutamatergic synapses in the hippocampus of juvenile rats, disclosing an …

Graphene Oxide Nanosheets Hamper Glutamate Mediated Excitotoxicity and Protect Neuronal Survival In An In vitro Stroke Model

L Tortella, I Santini, N Lozano… - … A European Journal, 2023 - Wiley Online Library
Small graphene oxide (s‐GO) nanosheets reversibly downregulate central nervous system
(CNS) excitatory synapses, with potential developments as future therapeutic tools to treat …

[HTML][HTML] The mechanical, optical, and thermal properties of graphene influencing its pre-clinical use in treating neurological diseases

T Ye, Y Yang, J Bai, FY Wu, L Zhang… - Frontiers in …, 2023 - frontiersin.org
Rapid progress in nanotechnology has advanced fundamental neuroscience and innovative
treatment using combined diagnostic and therapeutic applications. The atomic scale …

Intergenerational effects of low-dose graphene oxide exposure during pregnancy and lactation on mouse neurobehavior, reproduction and development

Y Chen, Z Cao, X Mi, H Yao, A Guo, P Yuan, B Jiang - Carbon, 2024 - Elsevier
Graphene oxide (GO), a promising biomedical nanomaterial, has attracted increasing
attention regarding its potential hazards to environment and health. However, data on its …

Improvement of synaptic plasticity by nanoparticles and the related mechanisms: Applications and prospects

A Chen, Y Kang, J Liu, J Wu, X Feng, M Wang… - Journal of Controlled …, 2022 - Elsevier
Synaptic plasticity is an important basis of learning and memory and participates in brain
network remodelling after different types of brain injury (such as that caused by …