The cellular proteome is a complex microcosm of structural and regulatory networks that
requires continuous surveillance and modification to meet the dynamic needs of the cell. It is …

Cells must be able to cope with the challenge of folding newly synthesized proteins and
refolding those that have become misfolded in the context of a crowded cytosol. One such …

Stress granules (SGs) are transient ribonucleoprotein (RNP) aggregates that form during
cellular stress and are increasingly implicated in human neurodegeneration. To study the …

Ribosomes that experience terminal stalls during translation are resolved by ribosome-
associated quality control (QC) pathways that oversee mRNA and nascent chain destruction …

Different polyubiquitin chain linkages direct substrates toward distinct cellular pathways. K63-
linked ubiquitylation is known to regulate proteasome-independent events such as signal …

Blockade antibodies of the immunoinhibitory receptor PD-1 can stimulate the anti-tumor
activity of T cells, but clinical benefit is limited to a fraction of patients. Evidence suggests that …

Apoptosis is a cell suicide process that is essential for development, tissue homeostasis and
human health. Impaired apoptosis is associated with a variety of human diseases, including …

Small ubiquitin-like modifier (SUMO) modification regulates numerous cellular processes.
Unlike ubiquitin, detection of endogenous SUMOylated proteins is limited by the lack of …

Protein ubiquitylation is involved in a plethora of cellular processes. While antibodies
directed at ubiquitin remnants (K-ɛ-GG) have improved the ability to monitor ubiquitylation …

Several neurodegenerative diseases including Alzheimer's Disease (AD) are characterized
by ubiquitin‐positive pathological protein aggregates. Here, an immunoaffinity approach is …