Malaria immunity in man and mosquito: insights into unsolved mysteries of a deadly infectious disease
PD Crompton, J Moebius, S Portugal… - Annual review of …, 2014 - annualreviews.org
Malaria is a mosquito-borne disease caused by parasites of the obligate intracellular
Apicomplexa phylum the most deadly of which, Plasmodium falciparum, prevails in Africa …
Apicomplexa phylum the most deadly of which, Plasmodium falciparum, prevails in Africa …
The march toward malaria vaccines
SL Hoffman, J Vekemans, TL Richie, PE Duffy - Vaccine, 2015 - Elsevier
In 2013 there were an estimated 584,000 deaths and 198 million clinical illnesses due to
malaria, the majority in sub-Saharan Africa. Vaccines would be the ideal addition to the …
malaria, the majority in sub-Saharan Africa. Vaccines would be the ideal addition to the …
Advancements in prophylactic and therapeutic nanovaccines
Vaccines activate suitable immune responses to fight against diseases but can possess
limitations such as compromised efficacy and immunogenic responses, poor stability, and …
limitations such as compromised efficacy and immunogenic responses, poor stability, and …
A comprehensive model for assessment of liver stage therapies targeting Plasmodium vivax and Plasmodium falciparum
A Roth, SP Maher, AJ Conway, R Ubalee… - Nature …, 2018 - nature.com
Malaria liver stages represent an ideal therapeutic target with a bottleneck in parasite load
and reduced clinical symptoms; however, current in vitro pre-erythrocytic (PE) models for …
and reduced clinical symptoms; however, current in vitro pre-erythrocytic (PE) models for …
Interrogating the Plasmodium Sporozoite Surface: Identification of Surface-Exposed Proteins and Demonstration of Glycosylation on CSP and TRAP by Mass …
Malaria parasite infection is initiated by the mosquito-transmitted sporozoite stage, a highly
motile invasive cell that targets hepatocytes in the liver for infection. A promising approach to …
motile invasive cell that targets hepatocytes in the liver for infection. A promising approach to …
A next-generation genetically attenuated Plasmodium falciparum parasite created by triple gene deletion
SA Mikolajczak, V Lakshmanan, M Fishbaugher… - Molecular therapy, 2014 - cell.com
Immunization with live-attenuated Plasmodium sporozoites completely protects against
malaria infection. Genetic engineering offers a versatile platform to create live-attenuated …
malaria infection. Genetic engineering offers a versatile platform to create live-attenuated …
Vaccination with sporozoites: models and correlates of protection
Despite continuous efforts, the century-old goal of eradicating malaria still remains. Multiple
control interventions need to be in place simultaneously to achieve this goal. In addition to …
control interventions need to be in place simultaneously to achieve this goal. In addition to …
What Is Known about the Immune Response Induced by Plasmodium vivax Malaria Vaccine Candidates?
C López, Y Yepes-Pérez, N Hincapié-Escobar… - Frontiers in …, 2017 - frontiersin.org
Malaria caused by Plasmodium vivax continues being one of the most important infectious
diseases around the world; P. vivax is the second most prevalent species and has the …
diseases around the world; P. vivax is the second most prevalent species and has the …
Exploring in vitro expression and immune potency in mice using mRNA encoding the Plasmodium falciparum malaria antigen, CelTOS
IN Waghela, KL Mallory, JA Taylor… - Frontiers in …, 2022 - frontiersin.org
The secreted malarial protein, Cell-Traversal protein for Ookinetes and Sporozoites
(CelTOS), is highly conserved among Plasmodium species, and plays a role in the invasion …
(CelTOS), is highly conserved among Plasmodium species, and plays a role in the invasion …
Preliminary characterization of Plasmodium vivax sporozoite antigens as pre-erythrocytic vaccine candidates
J Nicholas, SL De, P Thawornpan… - PLoS Neglected …, 2023 - journals.plos.org
Plasmodium vivax pre-erythrocytic (PE) vaccine research has lagged far behind efforts to
develop Plasmodium falciparum vaccines. There is a critical gap in our knowledge of PE …
develop Plasmodium falciparum vaccines. There is a critical gap in our knowledge of PE …