[HTML][HTML] Circulating ceramides as biomarkers of cardiovascular disease: Evidence from phenotypic and genomic studies
KA McGurk, BD Keavney, A Nicolaou - Atherosclerosis, 2021 - Elsevier
There is a need for new biomarkers of atherosclerotic cardiovascular disease (ACVD), the
main cause of death globally. Ceramides, a class of potent bioactive lipid mediators, have …
main cause of death globally. Ceramides, a class of potent bioactive lipid mediators, have …
Integrating lipidomics and genomics: emerging tools to understand cardiovascular diseases
R Tabassum, S Ripatti - Cellular and Molecular Life Sciences, 2021 - Springer
Cardiovascular diseases (CVDs) are the leading cause of mortality and morbidity worldwide
leading to 31% of all global deaths. Early prediction and prevention could greatly reduce the …
leading to 31% of all global deaths. Early prediction and prevention could greatly reduce the …
Comprehensive genetic analysis of the human lipidome identifies loci associated with lipid homeostasis with links to coronary artery disease
We integrated lipidomics and genomics to unravel the genetic architecture of lipid
metabolism and identify genetic variants associated with lipid species putatively in the …
metabolism and identify genetic variants associated with lipid species putatively in the …
Whole genome sequence analysis of blood lipid levels in> 66,000 individuals
Blood lipids are heritable modifiable causal factors for coronary artery disease. Despite well-
described monogenic and polygenic bases of dyslipidemia, limitations remain in discovery …
described monogenic and polygenic bases of dyslipidemia, limitations remain in discovery …
Concordant inter-laboratory derived concentrations of ceramides in human plasma reference materials via authentic standards
In this community effort, we compare measurements between 34 laboratories from 19
countries, utilizing mixtures of labelled authentic synthetic standards, to quantify by mass …
countries, utilizing mixtures of labelled authentic synthetic standards, to quantify by mass …
Lipids and amyotrophic lateral sclerosis: A two‐sample Mendelian randomization study
Objective Previous observational studies revealed a potential but partially controversial
relation between lipid metabolism and the risk of amyotrophic lateral sclerosis (ALS) …
relation between lipid metabolism and the risk of amyotrophic lateral sclerosis (ALS) …
Metabolomics to identify fingerprints of carotid atherosclerosis in nonobese metabolic dysfunction-associated fatty liver disease
C Shao, L Xu, P Lei, W Wang, S Feng, J Ye… - Journal of Translational …, 2023 - Springer
Background/aims Nonobese metabolic dysfunction-associated fatty liver disease (MAFLD) is
paradoxically associated with improved metabolic and pathological features at diagnosis but …
paradoxically associated with improved metabolic and pathological features at diagnosis but …
APOE ε2 resilience for Alzheimer's disease is mediated by plasma lipid species: Analysis of three independent cohort studies
Abstract Introduction The apolipoprotein E (APOE) genotype is the strongest genetic risk
factor for late‐onset Alzheimer's disease. However, its effect on lipid metabolic pathways …
factor for late‐onset Alzheimer's disease. However, its effect on lipid metabolic pathways …
The potential of integrating human and mouse discovery platforms to advance our understanding of cardiometabolic diseases
Cardiometabolic diseases encompass a range of interrelated conditions that arise from
underlying metabolic perturbations precipitated by genetic, environmental, and lifestyle …
underlying metabolic perturbations precipitated by genetic, environmental, and lifestyle …
Sphingolipids in the heart: from cradle to grave
Cardiovascular diseases are the leading cause of mortality worldwide and this has largely
been driven by the increase in metabolic disease in recent decades. Metabolic disease …
been driven by the increase in metabolic disease in recent decades. Metabolic disease …