The prevalence of obesity has tripled over the past four decades, imposing an enormous
burden on people's health. Polygenic (or common) obesity and rare, severe, early-onset …

The prevalence of type 2 diabetes and obesity has risen dramatically for decades and is
expected to rise further, secondary to the growing aging, sedentary population. The strain on …

Eating disorders (anorexia nervosa, bulimia nervosa and binge-eating disorder) are a
heterogeneous class of complex illnesses marked by weight and appetite dysregulation …

Metabolic diseases are the most common and rapidly growing health issues worldwide. The
massive population-based human genetics is crucial for the precise prevention and …

Overweight and obesity in childhood and adolescence represents one of the most
challenging public health problems of our century owing to its epidemic proportions and the …

Genome-wide discovery efforts have identified more than 500 genetic loci associated with
adiposity traits. The vast majority of these loci were found through large-scale meta-analyses …

Obesity is a common complex trait that elevates the risk for various diseases, including type
2 diabetes and cardiovascular disease. A combination of environmental and genetic factors …

Muller et al. have provided a strong critique of the Genome-Wide Association Studies
(GWAS) of body-mass index (BMI), arguing that the GWAS approach for the study of BMI is …

Mechanistic studies in rodents evidenced synaptic remodeling in neuronal circuits that
control food intake. However, the physiological relevance of this process is not well defined …

Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children. The
prognosis for patients with high-grade and metastatic disease is still very poor, and survivors …