Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme for the critical process of one-
carbon metabolism involving folate and homocysteine metabolisms. It is known that some …

Objectives To examine the strengths and limitations of existing data to provide guidance for
the use of folate supplements as treatment, with or without other psychotropic medications …

Background Psychiatric disorders have seriously affected human life, one of the risk genes
related to psychosis is the methylenetetrahydrofolatereductase (MTHFR) gene. This gene …

Methylenetetrahydrofolate reductase (MTHFR) is the key enzyme of folate/homocysteine
metabolic pathway. C677T polymorphism of MTHFR gene was reported as risk factor for …

Background The results of meta-analyses conducted by previous association studies
between total homocysteine and schizophrenia suggest that an elevated total homocysteine …

Objective. Several studies with contradictory results from different cultures about association
of methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in schizophrenia …

Background and purpose Immunological pathways play a crucial role in developing and
precipitating neuropsychiatric disorders. Although the exact pathogenesis of schizophrenia …

Previous studies examining the possible role of the methylenetetrahydrofolate reductase
(MTHFR) polymorphisms in the development of schizophrenia (SZ) and bipolar disorder …

Patients with schizophrenia (SCZ) exhibit higher suicide rates than the general population.
However, the molecular mechanism responsible for the high rate of suicidal behavior in SCZ …

Background: Increased levels of homocysteine have been observed in various psychiatric
disorders, among them in schizophrenia, depression and bipolar mood disorder. Of the …