Dedicator of cytokinesis 2 (DOCK2) can activate the downstream small G protein Rac and
regulate cytoskeletal reorganization. DOCK2 is essential for critical physiological processes …

Pleural injury and subsequent loculation is characterized by acute injury, sustained
inflammation and, when severe, pathologic tissue reorganization. While fibrin deposition is a …

Background: Lung cancer is associated with a high mortality rate and often complicated with
malignant pleural effusion (MPE), which has a very poor clinical outcome with a short life …

Progressive lung scarring because of persistent pleural organization often results in pleural
fibrosis (PF). This process affects patients with complicated parapneumonic pleural …

During the development of pleural fibrosis, pleural mesothelial cells (PMCs) undergo
phenotypic switching from differentiated mesothelial cells to mesenchymal cells (MesoMT) …

Idiopathic pulmonary fibrosis (IPF) is the most common chronic interstitial lung disease and
is characterized by progressive scarring of the lung. Transforming growth factor-β (TGF-β) …

Cardiac fibrosis following myocardial infarction (MI) seriously affects the prognosis and
survival rate of patients. This study aimed to determine the effect and regulation mechanism …

Renal fibrosis is the most important feature of the progression of chronic kidney disease
(CKD), and epithelial–mesenchymal transition (EMT) plays an important role in renal …

Epithelial–mesenchymal transition (EMT) contributes to airway remodeling, a predominant
feature of asthma. DOCK2 (dedicator of cytokinesis 2) is an innate immune signaling …

The pathology of atherosclerosis, a leading cause of mortality in patients with cardiovascular
disease, involves inflammatory phenotypic changes in vascular endothelial cells. This study …