Effective screening for major aneuploidies can be provided in the first trimester of
pregnancy. Screening by a combination of fetal nuchal translucency and maternal serum …

Objective To summarize by meta‐analysis the accumulated data on the screening
performance of second‐trimester sonographic markers for fetal trisomy 21. Methods We …

The death of a child is a special sorrow. No matter the circumstances, a child's death is a life-
altering experience. Except for the child who dies suddenly and without forewarning …

Background In 1968 the first antenatal diagnosis of Down's syndrome was made and
screening on the basis of selecting women of advanced maternal age for amniocentesis was …

To determine whether sonographic" markers" are associated with fetal Down syndrome
during the second trimester and to estimate the degree of risk of individual markers using …

ContextSecond-trimester prenatal ultrasound is widely used in an attempt to detect Down
syndrome in fetuses, but the accuracy of this method is unknown. ObjectiveTo determine the …

Objective To describe and test a method of individual risk assessment for fetal Down's
syndrome based on maternal age and second‐trimester ultrasound findings. Design A case …

The use of prenatal ultrasound has proven efficacious for the prenatal diagnosis of
chromosomal abnormalities. The first sonographic sign of Down syndrome, the thickened …

Hearing loss, auricular anomalies and middle ear infections are common findings in many
genetic disorders, but the mechanisms have remained unknown. We studied ear and …

Second‐trimester sonographic findings of fetal trisomy may include structural abnormalities
or sonographic markers of fetal aneuploidy. Unlike structural anomalies, sonographic …