The members of the Management and Therapy Subcommittee undertook an evidence-
based review of current dry eye therapies and management options. Management options …

Abstract The TFOS DEWS II Pathophysiology Subcommittee reviewed the mechanisms
involved in the initiation and perpetuation of dry eye disease. Its central mechanism is …

Dry eye disease is a multifactorial disorder of the tears and ocular surface characterized by
symptoms of dryness and irritation. Although the pathogenesis of dry eye disease is not fully …

Purpose: The purpose of this article is to review the evidence for the hypothesis that the core
mechanism of dry eye disease (DED) is inflammation, including evidence from recent basic …

Ocular allergy (OA) and dry eye disease (DED) are the most common ocular surface
disorders with a potential severe impact on the patient's quality of life. OA and DED may …

The etiology of dry eye disease (DED) is complex and not yet fully understood, but the
disease is now recognized as being associated with ocular surface inflammation. The latest …

Purpose To compare concentrations of tear cytokines in 3 groups composed of Sjögren
syndrome (SS) dry eye, non–Sjögren syndrome (non-SS) dry eye, and normal subjects …

Corneal nerves are instrumental to maintain cornea integrity through regulation of key
physiological functions such as tear secretion, blink reflex, and neuropeptide turnover …

Using metagenomics, continuing evidence has elicited how intestinal microbiota trigger
distant autoimmunity. Sjögren's syndrome (SS) is an autoimmune disease that affects the …

Purpose.: To determine cytokine and chemokine concentrations in the tears of patients with
dry eye disease (DED) and analyze the possible relationships with the clinical severity of …