The optimism of the early period of antimicrobial discovery has been tempered by the
emergence of bacterial strains with resistance to these therapeutics. Today, clinically …

The ascendancy of metallo-β-lactamases within the clinical sector, while not ubiquitous, has
nonetheless been dramatic; some reports indicate that nearly 30% of imipenem-resistant …

Therapeutic options for infections caused by gram-negative organisms expressing plasmid-
mediated AmpC β-lactamases are limited because these organisms are usually resistant to …

Abstract The Antimicrobial Availability Task Force (AATF) of the Infectious Diseases Society
of America (IDSA) has viewed with concern the decreasing investment by major …

The simplistic image of the bacterium as an isolated, planktonic, self-cloning automaton is
refuted. We now recognize bacteria as microorganisms of enormous diversity and …

Enterobacteriaceae, especially Klebsiella spp. producing extended-spectrum β-lactamases
(ESBLs) such as SHV and TEM types, have been established since the 1980s as a major …

To create a drug, nature's blueprints often have to be improved through semisynthesis or
total synthesis (chemical postevolution). Selected contributions from industrial and academic …

Pseudomonas aeruginosa strains exhibit significant variability in pathogenicity and
ecological flexibility. Such interstrain differences reflect the dynamic nature of the P …

Pseudomonas aeruginosa is one of the leading causes of nosocomial infections. Severe
infections, such as pneumonia or bacteraemia, are associated with high mortality rates and …

Objectives: The purpose of this work was to study the genetic determinants responsible for
extended-spectrum β-lactamase (ESBL) resistance of Salmonella isolated from Dutch …