Homocysteine metabolism as the target for predictive medical approach, disease prevention, prognosis, and treatments tailored to the person
L Koklesova, A Mazurakova, M Samec, K Biringer… - EPMA Journal, 2021 - Springer
Homocysteine (Hcy) metabolism is crucial for regulating methionine availability, protein
homeostasis, and DNA-methylation presenting, therefore, key pathways in post-genomic …
homeostasis, and DNA-methylation presenting, therefore, key pathways in post-genomic …
The association between MTHFR polymorphism and cervical cancer
JM Gong, Y Shen, WW Shan, YX He - Scientific reports, 2018 - nature.com
Cervical cancer is an extremely prevalent disease worldwide. The purpose of this study was
to illustrate the relationship between methylenetetrahydrofolate reductase (MTHFR) …
to illustrate the relationship between methylenetetrahydrofolate reductase (MTHFR) …
Genetic variants in RUNX3, AMD1 and MSRA in the methionine metabolic pathway and survival in nonsmall cell lung cancer patients
Abnormal methionine dependence in cancer cells has led to methionine restriction as a
potential therapeutic strategy. We hypothesized that genetic variants involved in methionine …
potential therapeutic strategy. We hypothesized that genetic variants involved in methionine …
Association study between genetic polymorphisms in folate metabolism and gastric cancer susceptibility in Chinese Han population: A case–control study
L Wei, F Niu, J Wu, F Chen, H Yang, J Li… - Molecular genetics & …, 2019 - Wiley Online Library
Background Gastric cancer (GC), the second leading cause of cancer mortality behind lung
cancer worldwide, is caused by both genetic and environmental factors. In this study, we …
cancer worldwide, is caused by both genetic and environmental factors. In this study, we …
[HTML][HTML] A single-nucleotide polymorphism (rs1805087) in the methionine synthase (METH) gene increases the risk of prostate cancer
X Zhang, J Tang, N Shen, K Ren - Aging (Albany NY), 2018 - ncbi.nlm.nih.gov
Methionine synthase (METH, ie, MTR) is a key enzyme in the folate pathway, which plays a
critical role in the synthesis, repair, and methylation of DNA. The association between METH …
critical role in the synthesis, repair, and methylation of DNA. The association between METH …
Association of MTR A2756G and MTRR A66G Polymorphisms With Male Infertility: An Updated Meta-Analysis
T Tariq, A Arshad, A Bibi, S Aslam… - American Journal of …, 2023 - journals.sagepub.com
The objective of the present study was to find out the association of folate genes MTR
A2756G and MTRR A66G polymorphisms with the risk of male infertility. The databases of …
A2756G and MTRR A66G polymorphisms with the risk of male infertility. The databases of …
Genome-Wide Meta-analysis of Gene–Environmental Interaction for Insulin Resistance Phenotypes and Breast Cancer Risk in Postmenopausal Women
Insulin resistance (IR)–related genetic variants are possibly associated with breast cancer,
and the gene–phenotype–cancer association could be modified by lifestyle factors including …
and the gene–phenotype–cancer association could be modified by lifestyle factors including …
Mendelian randomization study: the association between metabolic pathways and colorectal cancer risk
Background: The roles of obesity-related biomarkers and their molecular pathways in the
development of postmenopausal colorectal cancer (CRC) have been inconclusive. We …
development of postmenopausal colorectal cancer (CRC) have been inconclusive. We …
Post genome-wide gene-environment interaction study: the effect of genetically driven insulin resistance on breast cancer risk using Mendelian randomization
Purpose The role of insulin resistance (IR) in developing postmenopausal breast cancer has
not been thoroughly resolved and may be confounded by lifestyle factors such as obesity …
not been thoroughly resolved and may be confounded by lifestyle factors such as obesity …
Post Genome-Wide Gene–Environment Interaction Study Using Random Survival Forest: Insulin Resistance, Lifestyle Factors, and Colorectal Cancer Risk
Molecular and genetic pathways of insulin resistance (IR) connecting colorectal cancer and
obesity factors in postmenopausal women remain inconclusive. We examined the IR …
obesity factors in postmenopausal women remain inconclusive. We examined the IR …