Cholangiocarcinoma (CCA) encompasses diverse epithelial tumors historically associated
with poor outcomes due to an aggressive disease course, late diagnosis, and limited benefit …

The clinical use of molecular targeted therapy is rapidly evolving but has primarily focused
on genomic alterations. Transcriptomic analysis offers an opportunity to dissect the …

Only a minority of patients derive long-term clinical benefit from anti-programmed cell death
protein 1 (anti-PD-1) or anti-programmed death-ligand 1 (anti-PD-L1) monoclonal …

Molecular diagnostics is becoming one of the major drivers of personalized oncology. With
hundreds of different approved anticancer drugs and regimens of their administration …

Background The discovery of immune checkpoint inhibitors (ICIs) has revolutionized the
systemic approach to cancer treatment. Most patients receiving ICIs, however, do not derive …

Background Genomic alterations play important roles in the development of cancer. We
explored the impact of protein-coding genes and transcriptomic changes on clinical and …

This work addresses the fabrication of an efficient, novel, and economically viable
immunosensing armamentarium that will detect the carcinoembryonic antigen (CEA) …

The sequence assembly algorithms have rapidly evolved with the vigorous growth of
genome sequencing technology over the past two decades. Assembly mainly uses the …

Background Methods for identifying gene fusion events, such as fluorescence in situ
hybridization (FISH), immunohistochemistry (IHC), and transcriptome analysis, are either …

Objective To investigate the effects of bromine domain protein 4 (BRD4) inhibitor JQ1 on the
expression profile of super-enhancer-related lncRNAs (SE-lncRNAs) and mRNAs in cervical …