GABAA receptors are the major inhibitory transmitter receptors in the brain. They are ligand-
gated chloride channels and the site of action of benzodiazepines, barbiturates, neuroactive …

GABA (1, 4-aminobutanoic acid, γ-aminobutyric acid) is the major inhibitory neurotransmitter
in the brain and is essential for the overall balance between neuronal excitation and …

The sleep-aids zolpidem and eszopiclone exert their effects by binding to and modulating γ-
aminobutyric acid type-A receptors (GABAARs), but little is known about the structural …

The new generation hypnotic drugs, zolpidem, zopiclone and zaleplon, are at least as
efficacious in the clinic as benzodiazepines and may offer advantages in terms of safety …

This experiment was performed to investigate the anxiolytic-like effects of sanjoinine A, one
of the major alkaloid compounds in Zizyphi Spinosi Semen (ZSS), by using experimental …

The discovery of benzodiazepine receptors provided the impetus to discover and develop
anxioselective anxiolytics ('Valium without the side effects'). The market potential for an …

NMDA receptor hypofunction has been implicated in the pathophysiology of schizophrenia,
and pharmacological and genetic approaches have been used to model such dysfunction …

Indiplon (NBI 34060) is a novel pyrazolopyrimidine currently in development for the
treatment of insomnia. We have previously shown that indiplon exhibits high-affinity binding …

Dieses Werk bietet praxisorientierte, konkrete Handlungsanweisungen mit exakten
Dosierungsangaben und zahlreichen Tipps für die tägliche Praxis. Es liefert präzise …

Therapeutic Reviews aim to provide essential independent information for health
professionals about drugs used in palliative and hospice care. Additional content is …