The ability of cells to deal with different types of stressful situations in a precise and
coordinated manner is key for survival and involves various signalling networks. Over the …

Glycogen synthase kinase-3β (GSK-3β) is an evolutionarily conserved serine/threonine
kinase, functioning in numerous cellular processes including cell proliferation, DNA repair …

The molecular circuits by which antigens activate quiescent T cells remain poorly
understood. We combined temporal profiling of the whole proteome and phosphoproteome …

DNA damage occurs on exposure to genotoxic agents and during physiological DNA
transactions. DNA double-strand breaks (DSBs) are particularly dangerous lesions that …

The DNA damage response (DDR) is an organized network of multiple interwoven
components evolved to repair damaged DNA and maintain genome fidelity. Conceptually …

Abstract Glycogen synthase kinase-3 (GSK-3) is a ubiquitously expressed protein kinase
that sits at the nexus of multiple signaling pathways. Its deep integration into cellular control …

Overview: Long-term survival of T lymphocytes in quiescent state is essential to maintain
their cell numbers in secondary lymphoid organs and in peripheral circulation. In the …

Glioblastoma is the most aggressive primary brain cancer, which has no cure yet. Emerging
nanotheranostic alternatives such as magnetic iron oxide nanoparticles (MIONs) have great …

Resistance to genotoxic therapies is a primary cause of treatment failure and tumor
recurrence. The underlying mechanisms that activate the DNA damage response (DDR) and …

Polymer-drug conjugation is an attractive approach for target delivering insoluble and highly
toxic drugs to tumor sites to overcome the side-effects caused by cancer chemotherapy. In …