Single-cell analysis using Fourier transform infrared microspectroscopy

J Doherty, G Cinque, P Gardner - Applied Spectroscopy Reviews, 2017 - Taylor & Francis
Fourier transform infrared spectroscopy (FTIR) is a well-established, non-destructive method
of obtaining chemical information from biological samples such as tissues and cells. This …

Can mid-infrared biomedical spectroscopy of cells, fluids and tissue aid improvements in cancer survival? A patient paradigm

C Hughes, MJ Baker - Analyst, 2016 - pubs.rsc.org
This review will take a fresh approach from the patient perspective; offering insight into the
applications of mid-infrared biomedical spectroscopy in a scenario whereby the patient …

3D spectral imaging with synchrotron Fourier transform infrared spectro-microtomography

MC Martin, C Dabat-Blondeau, M Unger, J Sedlmair… - nature methods, 2013 - nature.com
We report Fourier transform infrared spectro-microtomography, a nondestructive three-
dimensional imaging approach that reveals the distribution of distinctive chemical …

Detection of an estrogen derivative in two breast cancer cell lines using a single core multimodal probe for imaging (SCoMPI) imaged by a panel of luminescent and …

S Clede, F Lambert, C Sandt, S Kascakova, M Unger… - Analyst, 2013 - pubs.rsc.org
3-Methoxy-17α-ethynylestradiol or mestranol is a prodrug for ethynylestradiol and the
estrogen component of some oral contraceptive formulations. We demonstrate here that a …

Development of a rapid detection protocol for microplastics using reflectance-FTIR spectroscopic imaging and multivariate classification

M Willans, E Szczecinski, C Roocke… - Environmental …, 2023 - pubs.rsc.org
Microplastics present a serious and worsening environmental threat to marine and aquatic
ecosystems. Continued monitoring is crucial in assessing the hazards and provenance of …

Subcellular biochemical investigation of purkinje neurons using synchrotron radiation fourier transform infrared spectroscopic imaging with a focal plane array detector

MJ Hackett, F Borondics, D Brown… - ACS chemical …, 2013 - ACS Publications
Coupling Fourier transform infrared spectroscopy with focal plane array detectors at
synchrotron radiation sources (SR-FTIR-FPA) has provided a rapid method to …

Toward optimal spatial and spectral quality in widefield infrared spectromicroscopy of IR labelled single cells

EC Mattson, M Unger, S Clède, F Lambert, C Policar… - Analyst, 2013 - pubs.rsc.org
Advancements in widefield infrared spectromicroscopy have recently been demonstrated
following the commissioning of IRENI (InfraRed ENvironmental Imaging), a Fourier …

Opportunities for live cell FT-infrared imaging: macromolecule identification with 2D and 3D localization

EC Mattson, E Aboualizadeh, ME Barabas… - International Journal of …, 2013 - mdpi.com
Infrared (IR) spectromicroscopy, or chemical imaging, is an evolving technique that is poised
to make significant contributions in the fields of biology and medicine. Recent developments …

Development of single-beam wide-field infrared imaging to study sub-cellular neuron biochemistry

MJ Hackett, S Caine, X Liu, TE May… - Vibrational Spectroscopy, 2015 - Elsevier
Multi-beam wide-field imaging using synchrotron mid-infrared light sources coupled with
focal plane array detectors has provided a major breakthrough to the field of bio …

Mapping sub-cellular protein aggregates and lipid inclusions using synchrotron ATR-FTIR microspectroscopy

D Hartnell, A Hollings, AM Ranieri, HB Lamichhane… - Analyst, 2021 - pubs.rsc.org
Visualising direct biochemical markers of cell physiology and disease pathology at the sub-
cellular level is an ongoing challenge in the biological sciences. A suite of microscopies …