Endothelial cells display remarkable phenotypic heterogeneity. An important goal is to
elucidate the scope and mechanisms of endothelial heterogeneity and to use this …

Probabilistic Boolean network (PBN) modelling is a semi-quantitative approach widely used
for the study of the topology and dynamic aspects of biological systems. The combined use …

Computational modeling and the theory of nonlinear dynamical systems allow one to not
simply describe the events of the cell cycle, but also to understand why these events occur …

The DNA replication–division cycle of eukaryotic cells is controlled by a complex network of
regulatory proteins, called cyclin-dependent kinases, and their activators and inhibitors …

An endogenous molecular--cellular network for both normal and abnormal functions is
assumed to exist. This endogenous network forms a nonlinear stochastic dynamical system …

In order for the cell's genome to be passed intact from one generation to the next, the events
of the cell cycle (DNA replication, mitosis, cell division) must be executed in the correct …

Background A key problem in the analysis of mathematical models of molecular networks is
the determination of their steady states. The present paper addresses this problem for …

Cancer is a complex disease: its pathology cannot be properly understood in terms of
independent players—genes, proteins, molecular pathways, or their simple combinations …

The PI3K/AKT signaling pathway plays a role in most cellular functions linked to cancer
progression, including cell growth, proliferation, cell survival, tissue invasion and …

Based on recent work, I will give a nontechnical brief review of a powerful quantitative
concept in biology, adaptive landscape, initially proposed by S. Wright over 70 years ago …