Long recognized as an evolutionarily ancient cell type involved in tissue homeostasis and
immune defense against pathogens, macrophages are being re-discovered as regulators of …

Advances in nanomedicine, including early cancer detection, targeted drug delivery, and
personalized approaches to cancer treatment are on the rise. For example, targeted drug …

Cholesterol metabolism produces essential membrane components as well as metabolites
with a variety of biological functions. In the tumour microenvironment, cell-intrinsic and cell …

Tumor-promoting inflammation and the avoidance of immune destruction are hallmarks of
cancer. While innate immune cells, such as neutrophils, monocytes, and macrophages, are …

Avoiding immune destruction is a hallmark of cancer. Over the past few years, significant
advances have been made in understanding immune dysfunction and immunosuppression …

Inflammation is the principal response invoked by the body to address injuries. Despite
inflammation constituting a crucial component of tissue repair, it is well known that …

Tumor-promoting inflammation and avoiding immune destruction are hallmarks of cancer.
Here, we demonstrate that the pro-inflammatory cytokine interleukin (IL)-18 is critically …

Redox regulation has been proposed to control various aspects of carcinogenesis, cancer
cell growth, metabolism, migration, invasion, metastasis and cancer vascularization. As …

The development of cancer immunotherapy, particularly immune checkpoint blockade
therapy, has made major breakthroughs in the therapy of cancers. However, less than one …

Metastasis remains the primary cause of small cell lung cancer (SCLC)-related deaths.
Growing evidence links tumor metastasis with a pre-metastatic microenvironment …