Breast cancer is the most common malignancy in women worldwide and is associated with
high mortality rates despite the continuously advancing treatment strategies. Glucose is …

Estrogens play a fundamental role in the physiology of the reproductive, cardiovascular,
skeletal, and central nervous systems. In this report, we review the literature in both rodents …

Nuclear-and membrane-initiated estrogen signaling cooperate to orchestrate the pleiotropic
effects of estrogens. Classical estrogen receptors (ERs) act transcriptionally and govern the …

Muscle wasting disease indications are among the most debilitating and often deadly
noncommunicable disease states. As a comorbidity, muscle wasting is associated with …

Considering the current trends in life expectancy, women in the modern era are challenged
with facing menopausal symptoms as well as heightened disease risk associated with …

The incidence of chronic disease is elevated in women after menopause. Increased
expression of ESR1 (the gene that encodes the estrogen receptor alpha, ERα) in muscle is …

Background The incidence of chronic disease is elevated in women after menopause.
Natural variation in muscle expression of the estrogen receptor (ER) α is inversely …

Impairment of skeletal muscle function has been associated with changes in ovarian
hormones, especially estradiol. To elucidate mechanisms of estradiol on skeletal muscle …

Estradiol deficiency in females can result in skeletal muscle strength loss, and treatment with
estradiol mitigates the loss. There are three primary estrogen receptors (ERs), and estradiol …

Estrogen (E2) has multiple functions in breast cancers including stimulating cancer growth
and interfering with chemotherapeutic efficacy. Heteronemin, a marine sesterterpenoid-type …