Statement on imaging and pulmonary hypertension from the Pulmonary Vascular Research Institute (PVRI)

DG Kiely, DL Levin, PM Hassoun, D Ivy… - Pulmonary …, 2019 - journals.sagepub.com
Pulmonary hypertension (PH) is highly heterogeneous and despite treatment advances it
remains a life-shortening condition. There have been significant advances in imaging …

Image‐based computational fluid dynamics in the lung: virtual reality or new clinical practice?

KS Burrowes, J De Backer… - … Reviews: Systems Biology …, 2017 - Wiley Online Library
The development and implementation of personalized medicine is paramount to improving
the efficiency and efficacy of patient care. In the respiratory system, function is largely …

Evolution of hemodynamic forces in the pulmonary tree with progressively worsening pulmonary arterial hypertension in pediatric patients

W Yang, M Dong, M Rabinovitch, FP Chan… - … and modeling in …, 2019 - Springer
Pulmonary arterial hypertension (PAH) is characterized by pulmonary vascular remodeling
resulting in right ventricular (RV) dysfunction and ultimately RV failure. Mechanical stimuli …

Patient-specific computational modeling of blood flow in the pulmonary arterial circulation

VO Kheyfets, L Rios, T Smith, T Schroeder… - Computer methods and …, 2015 - Elsevier
Computational fluid dynamics (CFD) modeling of the pulmonary vasculature has the
potential to reveal continuum metrics associated with the hemodynamic stress acting on the …

4D magnetic resonance flow imaging for estimating pulmonary vascular resistance in pulmonary hypertension

VO Kheyfets, M Schafer, CA Podgorski… - Journal of Magnetic …, 2016 - Wiley Online Library
Purpose To develop an estimate of pulmonary vascular resistance (PVR) using blood flow
measurements from 3D velocity‐encoded phase contract magnetic resonance imaging …

Simulation of unsteady blood flows in a patient‐specific compliant pulmonary artery with a highly parallel monolithically coupled fluid‐structure interaction algorithm

F Kong, V Kheyfets, E Finol… - International journal for …, 2019 - Wiley Online Library
Computational fluid dynamics (CFD) is increasingly used to study blood flows in patient‐
specific arteries for understanding certain cardiovascular diseases. The techniques work …

3D vortex‐energetics in the left pulmonary artery for differentiating pulmonary arterial hypertension and pulmonary venous hypertension groups using 4D flow MRI

MSM Elbaz, M Shafeghat, BH Freed… - Journal of Magnetic …, 2024 - Wiley Online Library
Background Pulmonary hypertension (PH) is a life‐threatening. Differentiation pulmonary
arterial hypertension (PAH) from pulmonary venous hypertension (PVH) is important due to …

Coagulation profiles of pulmonary arterial hypertension patients, assessed by non-conventional hemostatic tests and markers of platelet activation and endothelial …

E Vrigkou, AE Tsantes, P Kopterides, SE Orfanos… - Diagnostics, 2020 - mdpi.com
Many pathophysiologic processes of pulmonary arterial hypertension (PAH), namely, excess
vasoconstriction, vascular remodeling and in situ thrombosis, involve the coagulation …

Toward vasculature in skeletal muscle-on-a-chip through thermo-responsive sacrificial templates

L Wan, J Flegle, B Ozdoganlar, PR LeDuc - Micromachines, 2020 - mdpi.com
Developing new approaches for vascularizing synthetic tissue systems will have a
tremendous impact in diverse areas. One area where this is particularly important is …

Circulating miRNAs in pediatric pulmonary hypertension show promise as biomarkers of vascular function

VO Kheyfets, CC Sucharov, U Truong… - Oxidative medicine …, 2017 - Wiley Online Library
Background/Objectives. The objective of this study was to evaluate the utility of circulating
miRNAs as biomarkers of vascular function in pediatric pulmonary hypertension. Method …