Tumor suppressor genes cooperate with each other in tumors. Three important tumor
suppressor proteins, retinoblastoma (Rb), p53, phosphatase, and tensin homolog deleted …

Inorganic phosphate (Pi) is essential for signal transduction and cell metabolism, and is also
an essential structural component of the extracellular matrix of the skeleton. Pi is sensed in …

The catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) regulates cell death. We
sought to determine whether DNA-PKcs played a role in the tubular damage that occurs …

DNA-dependent protein kinase catalytic subunit (DNA-PKcs) is a novel housekeeper of
hepatic mitochondrial homeostasis outside the DNA repair process. In this study, DNA-PKcs …

Tumor suppressor p53 plays an important role in cancer prevention. Under normal
conditions, p53 is maintained at a low level. However, in response to various cellular …

The protein kinase CK2 (CK2) family encompasses a small number of acidophilic
serine/threonine kinases that phosphorylate substrates involved in numerous biological …

Cell signaling via inositol phosphates, in particular via the second messenger myo‐inositol
1, 4, 5‐trisphosphate, and phosphoinositides comprises a huge field of biology. Of the nine …

Diphosphorylated inositol polyphosphates, also referred to as inositol pyrophosphates, are
important signaling molecules that regulate critical cellular activities in many eukaryotic …

The combinatorial phosphorylation of myo-inositol results in the generation of different
inositol phosphates (InsPs), of which phytic acid (InsP6) is the most abundant species in …

Inositol pyrophosphates are small, diffusible signaling molecules that possess the most
concentrated three‐dimensional array of phosphate groups in Nature; up to eight …