Organoid-on-a-chip and body-on-a-chip systems for drug screening and disease modeling

A Skardal, T Shupe, A Atala - Drug discovery today, 2016 - Elsevier
Highlights•Traditional drug screening model systems are inadequate.•Organoid-on-a-chip
platforms stand to significantly advance drug and toxicology screening.•A wide variety or …

Review of synthetic and hybrid scaffolds in cartilage tissue engineering

M Wasyłeczko, W Sikorska, A Chwojnowski - Membranes, 2020 - mdpi.com
Cartilage tissue is under extensive investigation in tissue engineering and regenerative
medicine studies because of its limited regenerative potential. Currently, many scaffolds are …

Engineering immunomodulatory biomaterials to tune the inflammatory response

A Vishwakarma, NS Bhise, MB Evangelista… - Trends in …, 2016 - cell.com
Current state-of-the-art biomedical implants and tissue engineering methods promise
technologies to improve or even restore the function of diseased organs. However, one of …

3D bioprinting in otolaryngology: A review

A McMillan, N McMillan, N Gupta… - Advanced …, 2023 - Wiley Online Library
The evolution of tissue engineering and 3D bioprinting has allowed for increased
opportunities to generate musculoskeletal tissue grafts that can enhance functional and …

Stem cells and regenerative medicine: myth or reality of the 21th century

JF Stoltz, N de Isla, YP Li, D Bensoussan… - Stem cells …, 2015 - Wiley Online Library
Since the 1960s and the therapeutic use of hematopoietic stem cells of bone marrow origin,
there has been an increasing interest in the study of undifferentiated progenitors that have …

Chitosan‐based nanocomposites for medical applications

S Murugesan, T Scheibel - Journal of Polymer Science, 2021 - Wiley Online Library
Chitosan as a biobased polymer is gaining increasing attention due to its extraordinary
physico‐chemical characteristics and properties. While a primary use of chitosan has been …

Convergence of microengineering and cellular self-organization towards functional tissue manufacturing

J Laurent, G Blin, F Chatelain, V Vanneaux… - Nature Biomedical …, 2017 - nature.com
Technical progress in materials science and bioprinting has for the past few decades
fostered considerable advances in medicine. More recently, the understanding of the …

Recent advances in pharmaceutical and biotechnological applications of lignin-based materials

Y Mukheja, J Kaur, K Pathania, SP Sah… - International Journal of …, 2023 - Elsevier
Lignin, a versatile and abundant biomass-derived polymer, possesses a wide array of
properties that makes it a promising material for biotechnological applications. Lignin holds …

Strategies for developing decellularized corneal scaffolds

AP Lynch, M Ahearne - Experimental eye research, 2013 - Elsevier
The main obstacle to successfully engineering corneal tissue has been the replication of the
structural and biochemical composition of native cornea in a scaffold. In recent years …

Integrating valve-inspired design features into poly (ethylene glycol) hydrogel scaffolds for heart valve tissue engineering

X Zhang, B Xu, DS Puperi, AL Yonezawa, Y Wu… - Acta biomaterialia, 2015 - Elsevier
The development of advanced scaffolds that recapitulate the anisotropic mechanical
behavior and biological functions of the extracellular matrix in leaflets would be …