Janus protein tyrosine kinase (JAK) has the ability to activate signal transducer and activator
of transcription (STAT). STAT3 is a valued member of the JAK/STAT signaling pathway. In …

The liver is sensitive to pathogen-induced acute or chronic liver injury, and liver
transplantation (LT) is the only effective strategy for end-stage liver diseases. However, the …

Background Intrauterine adhesion (IUA) is one of the most serious complications in patients
with endometrial repair disorder after injury. Currently, there is no effective treatment for IUA …

In recent decades, mesenchymal stromal cells (MSCs) biomedical utilizing has attracted
worldwide growing attention. After the first report of the human MSCs obtaining from the …

Liver fibrosis is the common pathological basis of all chronic liver diseases, and is the
necessary stage for the progression of chronic liver disease to cirrhosis. As one of …

Inflammation has been known to be an important driver of fibrogenesis in the liver and onset
of hepatic fibrosis. It starts off as a process meant to protect the liver from further damage, but …

Background Liver fibrosis is a significant challenge to global health that results in organ
failure through inflammation and the release of fibrotic biomarkers. Due to the lack of …

Fibrosis is a common feature in most pathogenetic processes in the liver, and usually results
from a chronic insult that depletes the regenerative capacity of hepatocytes and activates …

Abstract Objectives Emerging microRNAs (miRNAs) are validated to take part in
pathological processes, including numerous carcinomas. Currently, we focused on the …

Although multiple drugs are accessible for recovering liver function in patients, none are
considered efficient. Liver transplantation is the mainstay therapy for end-stage liver fibrosis …