To a large extent, cancer conforms to evolutionary rules defined by the rates at which clones
mutate, adapt and grow. Next-generation sequencing has provided a snapshot of the …

Context Despite the lack of level 1 evidence, metastasis-directed therapy (MDT) is used
widely in the management of metastatic prostate cancer (mPCa) patients. Data are …

PURPOSE Our previously published findings reported that local consolidative therapy (LCT)
with radiotherapy or surgery improved progression-free survival (PFS) and delayed new …

Importance Patterns-of-failure studies suggest that in metastatic non–small-cell lung cancer
(NSCLC) sites of gross disease at presentation are the first to progress when treated with …

Importance Patients with oligometastatic non–small cell lung cancer (NSCLC) may benefit
from locally ablative therapy (LAT) such as surgery or stereotactic radiotherapy. Prior studies …

Technological advances and clinical research over the past few decades have given
radiation oncologists the capability to personalize treatments for accurate delivery of …

Introduction Improved outcome has been shown in patients with synchronous
oligometastatic (sOM) NSCLC when treated with radical intent. As a uniform definition of …

Subclinical prostate cancer is common in men> 50 years. Population-based screening of
men aged between 55 and 69 years, using prostate-specific antigen (PSA) testing, has been …

Radiation therapy (RT) plays a key role in curative-intent treatments for head and neck
cancers. Its use is indicated as a sole therapy in early stage tumors or in combination with …

Metastasis is initiated and sustained through therapy by cancer cells with stem-like and
immune-evasive properties, termed metastasis-initiating cells (MIC). Recent progress …