Cytokine storm and leukocyte changes in mild versus severe SARS-CoV-2 infection: Review of 3939 COVID-19 patients in China and emerging pathogenesis and …

J Wang, M Jiang, X Chen… - Journal of Leucocyte …, 2020 - academic.oup.com
Clinical evidence indicates that the fatal outcome observed with severe acute respiratory
syndrome-coronavirus-2 infection often results from alveolar injury that impedes airway …

Conceptual approaches to modulating antibody effector functions and circulation half-life

KO Saunders - Frontiers in immunology, 2019 - frontiersin.org
Antibodies and Fc-fusion antibody-like proteins have become successful biologics
developed for cancer treatment, passive immunity against infection, addiction, and …

Considerations for the design of antibody-based therapeutics

DR Goulet, WM Atkins - Journal of pharmaceutical sciences, 2020 - Elsevier
Antibody-based proteins have become an important class of biologic therapeutics, due in
large part to the stability, specificity, and adaptability of the antibody framework. Indeed …

Overcoming resistance to natural killer cell based immunotherapies for solid tumors

G Nayyar, Y Chu, MS Cairo - Frontiers in oncology, 2019 - frontiersin.org
Despite advances in the diagnostic and therapeutic modalities, the prognosis of several
solid tumor malignancies remains poor. Different factors associated with solid tumors …

Neutrophils in cancer

LW Treffers, IH Hiemstra, TW Kuijpers… - Immunological …, 2016 - Wiley Online Library
Neutrophils play an important role in cancer. This does not only relate to the well‐
established prognostic value of the presence of neutrophils, either in the blood or in tumor …

[HTML][HTML] Plasticity in pro-and anti-tumor activity of neutrophils: shifting the balance

C Furumaya, P Martinez-Sanz, P Bouti… - Frontiers in …, 2020 - frontiersin.org
Over the last decades, cancer immunotherapies such as checkpoint blockade and adoptive
T cell transfer have been a game changer in many aspects and have improved the treatment …

New immune cell engagers for cancer immunotherapy

A Fenis, O Demaria, L Gauthier, E Vivier… - Nature Reviews …, 2024 - nature.com
There have been major advances in the immunotherapy of cancer in recent years, including
the development of T cell engagers—antibodies engineered to redirect T cells to recognize …

Therapeutic antibodies: what have we learnt from targeting CD20 and where are we going?

MJE Marshall, RJ Stopforth, MS Cragg - Frontiers in immunology, 2017 - frontiersin.org
Therapeutic monoclonal antibodies (mAbs) have become one of the fastest growing classes
of drugs in recent years and are approved for the treatment of a wide range of indications …

Potent Fc receptor signaling by IgA leads to superior killing of cancer cells by neutrophils compared to IgG

AM Brandsma, S Bondza, M Evers, R Koutstaal… - Frontiers in …, 2019 - frontiersin.org
Antibody therapy of cancer is increasingly used in the clinic and has improved patient's life
expectancy. Except for immune checkpoint inhibition, the mode of action of many antibodies …

The present and future of immunocytokines for cancer treatment

DY Gout, LS Groen, M van Egmond - Cellular and Molecular Life Sciences, 2022 - Springer
Monoclonal antibody (mAb) therapy has successfully been introduced as treatment of
several lymphomas and leukemias. However, solid tumors reduce the efficacy of mAb …