Since the discovery of sickle cell disease (SCD) in 1910, enormous strides have been made
in the elucidation of the pathogenesis of its protean complications, which has inspired recent …

In spite of significant strides in the treatment of sickle cell disease (SCD), SCD crises are still
responsible for high morbidity and early mortality. While most patients initially seek care in …

1Department of Haematology, Guy's and St Thomas' NHS Foundation Trust, 2Lane Fox
Respiratory Unit, St Thomas' Hospital, Guy's and St Thomas' NHS Foundation Trust …

Acute chest syndrome (ACS) is a common complication and reason for hospital admission in
patients with sickle cell disease (SCD). It is also the most common cause of death in this …

Background: Pulmonary complications of sickle cell disease (SCD) are diverse and
encompass acute and chronic disease. The understanding of the natural history of …

Sickle cell disease (SCD) is an inherited haemoglobin disorder, associated with recurrent
painful episodes, ongoing haemolytic anaemia and progressive multi-organ damage. Until …

Introduction Sickle cell disease, one of the world's most prevalent Mendelian disorders, is a
chronic hemolytic anemia punctuated by acute vasoocclusive events. Both hemolysis and …

Sickle cell disease (SCD), the most common genetic hemolytic anemia worldwide, affects
250,000 births annually. In the United States, SCD affects approximately 100,000 …

Objectives To prospectively assess longitudinal lung function in children with sickle cell
disease (SCD). Working hypothesis Lung function in SCD children deteriorates with …

Introduction Acute chest syndrome (ACS) in sickle cell disease (SCD) is a serious condition
that carries with it a high rate of morbidity and mortality. Objective This review highlights the …