Gene drives gaining speed
E Bier - Nature Reviews Genetics, 2022 - nature.com
Gene drives are selfish genetic elements that are transmitted to progeny at super-Mendelian
(> 50%) frequencies. Recently developed CRISPR–Cas9-based gene-drive systems are …
(> 50%) frequencies. Recently developed CRISPR–Cas9-based gene-drive systems are …
Combating mosquito-borne diseases using genetic control technologies
Mosquito-borne diseases, such as dengue and malaria, pose significant global health
burdens. Unfortunately, current control methods based on insecticides and environmental …
burdens. Unfortunately, current control methods based on insecticides and environmental …
Efficient population modification gene-drive rescue system in the malaria mosquito Anopheles stephensi
Abstract Cas9/gRNA-mediated gene-drive systems have advanced development of genetic
technologies for controlling vector-borne pathogen transmission. These technologies …
technologies for controlling vector-borne pathogen transmission. These technologies …
Core commitments for field trials of gene drive organisms
Gene drive organisms (GDOs), whose genomes have been genetically engineered to
spread a desired allele through a population, have the potential to transform the way …
spread a desired allele through a population, have the potential to transform the way …
Symbionts and gene drive: two strategies to combat vector-borne disease
Mosquitoes bring global health problems by transmitting parasites and viruses such as
malaria and dengue. Unfortunately, current insecticide-based control strategies are only …
malaria and dengue. Unfortunately, current insecticide-based control strategies are only …
A CRISPR homing gene drive targeting a haplolethal gene removes resistance alleles and successfully spreads through a cage population
Engineered gene drives are being explored as a new strategy in the fight against vector-
borne diseases due to their potential for rapidly spreading genetic modifications through a …
borne diseases due to their potential for rapidly spreading genetic modifications through a …
Inherently confinable split-drive systems in Drosophila
CRISPR-based gene-drive systems, which copy themselves via gene conversion mediated
by the homology-directed repair (HDR) pathway, have the potential to revolutionize vector …
by the homology-directed repair (HDR) pathway, have the potential to revolutionize vector …
Manipulating the destiny of wild populations using CRISPR
Genetic biocontrol aims to suppress or modify populations of species to protect public
health, agriculture, and biodiversity. Advancements in genome engineering technologies …
health, agriculture, and biodiversity. Advancements in genome engineering technologies …
Computational and experimental performance of CRISPR homing gene drive strategies with multiplexed gRNAs
The rapid evolution of resistance alleles poses a major obstacle for genetic manipulation of
populations with CRISPR homing gene drives. One proposed solution is using multiple …
populations with CRISPR homing gene drives. One proposed solution is using multiple …
Anopheles homing suppression drive candidates exhibit unexpected performance differences in simulations with spatial structure
Recent experiments have produced several Anopheles gambiae homing gene drives that
disrupt female fertility genes, thereby eventually inducing population collapse. Such drives …
disrupt female fertility genes, thereby eventually inducing population collapse. Such drives …