The role of placental hormones in mediating maternal adaptations to support pregnancy and lactation
T Napso, HEJ Yong, J Lopez-Tello… - Frontiers in …, 2018 - frontiersin.org
During pregnancy, the mother must adapt her body systems to support nutrient and oxygen
supply for growth of the baby in utero and during the subsequent lactation. These include …
supply for growth of the baby in utero and during the subsequent lactation. These include …
The placenta‐brain‐axis
CS Rosenfeld - Journal of neuroscience research, 2021 - Wiley Online Library
All mammalian species depend on the placenta, a transient organ, for exchange of gases,
nutrients, and waste between the mother and conceptus. Besides serving as a conduit for …
nutrients, and waste between the mother and conceptus. Besides serving as a conduit for …
Dynamics of tryptophan metabolic pathways in human placenta and placental-derived cells: effect of gestation age and trophoblast differentiation
R Karahoda, C Abad, H Horackova… - Frontiers in cell and …, 2020 - frontiersin.org
l-Tryptophan is an essential amino acid and a precursor of several physiologically active
metabolites. In the placenta, the serotonin and kynurenine metabolic pathways of tryptophan …
metabolites. In the placenta, the serotonin and kynurenine metabolic pathways of tryptophan …
Prenatal stress causes intrauterine inflammation and serotonergic dysfunction, and long-term behavioral deficits through microbe-and CCL2-dependent mechanisms
Prenatal stress (PNS) is associated with neuropsychiatric disorders in offspring, including
anxiety, depression, and autism spectrum disorders. There is mounting evidence that these …
anxiety, depression, and autism spectrum disorders. There is mounting evidence that these …
Pathway of maternal serotonin to the human embryo and fetus
HJ Kliman, SB Quaratella, AC Setaro… - …, 2018 - academic.oup.com
Abstract Serotonin [5-hydroxytryptamine (5-HT)] is essential to intrauterine development, but
its source is debated. We used immunocytochemistry to gauge 5-HT, its biosynthetic enzyme …
its source is debated. We used immunocytochemistry to gauge 5-HT, its biosynthetic enzyme …
Serotonin system in the human placenta–the knowns and unknowns
M Perić, I Bečeheli, L Čičin-Šain, G Desoye… - Frontiers in …, 2022 - frontiersin.org
The biogenic monoamine serotonin (5-hydroxytryptamine, 5-HT) is a chemical messenger
widely distributed in the brain and various other organs. Its homeostasis is maintained by the …
widely distributed in the brain and various other organs. Its homeostasis is maintained by the …
Serotonin homeostasis in the materno‐foetal interface at term: Role of transporters (SERT/SLC6A4 and OCT3/SLC22A3) and monoamine oxidase A (MAO‐A) in …
R Karahoda, H Horackova, P Kastner… - Acta …, 2020 - Wiley Online Library
Aim Serotonin is crucial for proper foetal development, and the placenta has been described
as a 'donor'of serotonin for the embryo/foetus. However, in later stages of gestation the …
as a 'donor'of serotonin for the embryo/foetus. However, in later stages of gestation the …
Serotonin, hematopoiesis and stem cells
G Fouquet, T Coman, O Hermine, F Côté - Pharmacological research, 2019 - Elsevier
A large number of studies have focused on the role of serotonin as a neurotransmitter in the
central nervous system, although only a small percentage of the body's serotonin (∼ 5%) …
central nervous system, although only a small percentage of the body's serotonin (∼ 5%) …
Molecular pathways in placental-fetal development and disruption
The first trimester of pregnancy ranks high in priority when minimizing harmful exposures,
given the wide-ranging types of organogenesis occurring between 4-and 12-weeks' …
given the wide-ranging types of organogenesis occurring between 4-and 12-weeks' …
Serotonin-estrogen interactions: What can we learn from pregnancy?
AAH Thibeault, JT Sanderson, C Vaillancourt - Biochimie, 2019 - Elsevier
We have reviewed the scientific literature related to four diseases in which to serotonin (5-
HT) is involved in the etiology, herein named 5-HT-linked diseases, and whose prevalence …
HT) is involved in the etiology, herein named 5-HT-linked diseases, and whose prevalence …