During pregnancy, the mother must adapt her body systems to support nutrient and oxygen
supply for growth of the baby in utero and during the subsequent lactation. These include …

All mammalian species depend on the placenta, a transient organ, for exchange of gases,
nutrients, and waste between the mother and conceptus. Besides serving as a conduit for …

l-Tryptophan is an essential amino acid and a precursor of several physiologically active
metabolites. In the placenta, the serotonin and kynurenine metabolic pathways of tryptophan …

Prenatal stress (PNS) is associated with neuropsychiatric disorders in offspring, including
anxiety, depression, and autism spectrum disorders. There is mounting evidence that these …

Abstract Serotonin [5-hydroxytryptamine (5-HT)] is essential to intrauterine development, but
its source is debated. We used immunocytochemistry to gauge 5-HT, its biosynthetic enzyme …

The biogenic monoamine serotonin (5-hydroxytryptamine, 5-HT) is a chemical messenger
widely distributed in the brain and various other organs. Its homeostasis is maintained by the …

Aim Serotonin is crucial for proper foetal development, and the placenta has been described
as a 'donor'of serotonin for the embryo/foetus. However, in later stages of gestation the …

A large number of studies have focused on the role of serotonin as a neurotransmitter in the
central nervous system, although only a small percentage of the body's serotonin (∼ 5%) …

The first trimester of pregnancy ranks high in priority when minimizing harmful exposures,
given the wide-ranging types of organogenesis occurring between 4-and 12-weeks' …

We have reviewed the scientific literature related to four diseases in which to serotonin (5-
HT) is involved in the etiology, herein named 5-HT-linked diseases, and whose prevalence …