The IL-1 cytokine family comprises 11 members (7 ligands with agonist activity, 3 receptor
antagonists and 1 anti-inflammatory cytokine) and is recognised as a key mediator of …

Fibroblasts are non-haematopoietic structural cells that define the architecture of organs,
support the homeostasis of tissue-resident cells and have key roles in fibrosis, cancer …

Pathological remodeling of the extracellular matrix (ECM) by fibroblasts leads to organ
failure. Development of idiopathic pulmonary fibrosis (IPF) is characterized by a progressive …

The correct balance between collagen synthesis and degradation is essential for almost
every aspect of life, from development to healthy aging, reproduction and wound healing …

Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disorder driven by
unrelenting extracellular matrix deposition. Fibroblasts are recognized as the central …

In this study, we explored the regulation and the role of up-regulated microRNAs in
idiopathic pulmonary fibrosis (IPF), a progressive interstitial lung disease of unknown origin …

Molecular patterns and pathways in idiopathic pulmonary fibrosis (IPF) have been
extensively investigated, but few studies have assimilated multiomic platforms to provide an …

Idiopathic pulmonary fibrosis (IPF) is characterized by aberrant accumulation of collagen-
secreting myofibroblasts. Development of effective therapies is limited due to incomplete …

STAT3 is a latent transcription factor that plays a role in regulating fibroblast function in
fibrotic lung diseases. To further understand the role of STAT3 in the phenotypic divergence …

Excessive fibroproliferation is a central hallmark of idiopathic pulmonary fibrosis (IPF), a
chronic, progressive disorder that results in impaired gas exchange and respiratory failure …