Infectious diseases continue to be one of the major contributors to human morbidity. The
rapid rate at which pathogenic microorganisms have developed resistance against frontline …

Ventilator-associated pneumonia (VAP) is an unresolved problem in nosocomial settings,
remaining consistently associated with a lack of treatment, high mortality, and prolonged …

The escalating emergence of multidrug-resistant (MDR) pathogens and their ability to
colonize into biofilms on a multitude of surfaces have struck global health as a nightmare …

Encrypted peptides have been recently found in the human proteome and represent a
potential class of antibiotics. Here we report three peptides derived from the human …

Although antimicrobial peptides (AMPs) hold tremendous promise in overcoming the threats
of multidrug resistance, the main obstacle to successful therapeutic applications is their poor …

This is the first report of the design of a new series of symmetric xanthone derivatives that
mimic antimicrobial peptides using a total synthesis approach. This novel design is …

In this study, we report on the first chemical synthesis of ultra-short pyrazole-arginine based
antimicrobial peptidomimetics derived from the newly synthesized N-alkyl/aryl pyrazole …

Cecropin A is a novel 37‐residue cecropin‐like antimicrobial peptide isolated from the
cecropia moth, Hyalophora cecropia. We have demonstrated that cecropin A is an …

Hydrophobic interactions govern specificity for natural antimicrobial peptides. No such
relationship has been established for synthetic peptoids that mimic antimicrobial peptides …

The search for novel compounds to combat multi-resistant bacterial infections includes
exploring the potency of antimicrobial peptides and derivatives thereof. Complementary to …