Bacterial multidrug efflux pumps have come to prominence in human and veterinary
pathogenesis because they help bacteria protect themselves against the antimicrobials …

Membrane proteins play critical physiological roles in all organisms, from ion transport and
signal transduction to multidrug resistance. Elucidating their 3D structures is essential for …

The EcoCyc model-organism database collects and summarizes experimental data for
Escherichia coli K-12. EcoCyc is regularly updated by the manual curation of individual …

Bacteria harness an impressive repertoire of resistance mechanisms to evade the inhibitory
action of antibiotics. One such mechanism involves efflux pump-mediated extrusion of drugs …

Nitrogen availability is a growth-limiting factor in many habitats, and the global nitrogen
cycle involves prokaryotes and eukaryotes competing for this precious resource. Only some …

The dimeric transporter, EmrE, effluxes polyaromatic cationic drugs in a proton-coupled
manner to confer multidrug resistance in bacteria. Although the protein is known to adopt an …

Membrane proteins are often challenging targets for native top-down mass spectrometry
experimentation. The requisite use of membrane mimetics to solubilize such proteins …

Efflux pumps function as an advanced defense system against antimicrobials by reducing
the concentration of drugs inside the bacteria and extruding the substances outside. Various …

By providing broad resistance to environmental biocides, transporters from the small
multidrug resistance (SMR) family drive the spread of multidrug resistance cassettes among …

An intriguing consequence of ongoing riboswitch discovery efforts is the occasional
identification of metabolic or toxicity response pathways for unusual ligands. Recently, we …